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Pink1 PTEN Induced Putative Kinase 1 Monoclonal Antibody (N4/49)

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Pink1 PTEN Induced Putative Kinase 1 Monoclonal Antibody (N4/49)

产品信息

75-061

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:1,000
-

免疫组化（冰冻） (IHC (F))

Assay-dependent
-

免疫细胞化学 (ICC/IF)

Assay-dependent
-

酶联免疫吸附实验 (ELISA)

Assay-dependent
-
产品规格

种属反应

Human

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

N4/49

抗原

Fusion protein amino acids 112-496 of human Pink1 (accession number NP_115785) produced recombinantly in E. Coli.
3D表位/免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

规格

100 µg

纯化类型

Protein A

保存液

TBS, pH 7.4

内含物

0.065% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Dry ice (international)

产品详细信息

For maximum recovery of product, centrifuge the vial prior to removing the cap.

靶标信息

PINK1 (PTEN-induced putative kinase 1) protects from mitochondrial dysfunction in cells by conferring different autophosphorylation activity to mitochondrial genes. The kinase domain of PINK1 appears to be critical in its protective effects. Mitochondrial proteins are critical for the regulation of cellular energy and adaptation to stress. Particularly in brain cells, mitochondrial demand is extraordinarily high, in order to accommodate aerobic and anaerobic support of high energy processes. When mitochondrial structure and/or function is disrupted in the brain, neurodegenerative diseases like Parkinson's disease are triggered.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: FLJ27236; PINK 1; PINK-1; protein kinase BRPK; PTEN induced putative kinase 1; PTEN-induced putative kinase protein 1; unnamed protein product

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基因别名: BRPK; PARK6

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UniProt ID: (Human) Q9BXM7

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Entrez Gene ID: (Human) 65018

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功能
magnesium ion binding protease binding protein kinase activity protein serine/threonine kinase activity protein binding ATP binding kinase activity peptidase activator activity kinase binding ubiquitin protein ligase binding protein kinase B binding macromolecular complex binding C3HC4-type RING finger domain binding protein serine kinase activity
参与通路
mitophagy mitophagy regulation of oxidative phosphorylation response to ischemia protein phosphorylation ubiquitin-dependent protein catabolic process response to stress response to oxidative stress mitochondrion organization regulation of hydrogen peroxide metabolic process negative regulation of gene expression regulation of mitochondrion organization macroautophagy positive regulation of macroautophagy negative regulation of macroautophagy protein ubiquitination respiratory electron transport chain hemopoiesis positive regulation of cell migration regulation of protein ubiquitination positive regulation of protein ubiquitination cellular response to oxidative stress intracellular signal transduction TORC2 signaling regulation of apoptotic process negative regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling regulation of protein complex assembly regulation of neuron apoptotic process negative regulation of neuron apoptotic process positive regulation of translation positive regulation of transcription from RNA polymerase II promoter negative regulation of JNK cascade protein stabilization regulation of mitochondrial membrane potential positive regulation of protein kinase B signaling regulation of proteasomal protein catabolic process protein localization to mitochondrion cellular response to hypoxia maintenance of protein location in mitochondrion positive regulation of mitochondrial fission positive regulation of release of cytochrome c from mitochondria negative regulation of mitochondrial fission cellular response to toxic substance mitochondrion to lysosome transport regulation of cellular response to oxidative stress negative regulation of macromitophagy regulation of synaptic vesicle transport negative regulation of autophagosome assembly positive regulation of mitochondrial electron transport, NADH to ubiquinone regulation of mitophagy negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway regulation of protein localization to mitochondrion positive regulation of establishment of protein localization to mitochondrion negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide positive regulation of cristae formation positive regulation of free ubiquitin chain polymerization cellular response to hydrogen sulfide positive regulation of type 2 mitophagy regulation of reactive oxygen species metabolic process negative regulation of reactive oxygen species metabolic process positive regulation of ATP biosynthetic process negative regulation of intrinsic apoptotic signaling pathway
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