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Invitrogen
Plasminogen Kringle 5 Polyclonal Antibody
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产品信息
PA5-149354
产品规格
种属反应
Mouse
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E. coli-derived recombinant mouse Plasminogen Kringle 5, Cys481-Ala563
偶联物
形式
Lyophilized
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with trehalose
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute at 0.2 mg/mL in sterile PBS.
靶标信息
Plasminogen Kringle 5 is a domain within the plasminogen gene, which encodes the precursor to plasmin, an important enzyme involved in the breakdown of blood clots (fibrinolysis). The plasminogen protein contains multiple kringle domains, each contributing to its function. Kringle 5, in particular, has garnered interest due to its potent anti-angiogenic properties, meaning it can inhibit the formation of new blood vessels. This function is crucial in regulating processes such as wound healing, tissue regeneration, and the suppression of tumor growth, as tumors often rely on angiogenesis to obtain nutrients and grow. Kringle 5 exerts its effects by binding to specific receptors on endothelial cells, thereby inhibiting their proliferation and migration. This makes it a promising target for therapeutic strategies aimed at treating diseases characterized by excessive angiogenesis, such as cancer and certain eye diseases like diabetic retinopathy and age-related macular degeneration. Understanding the mechanisms of action and regulatory pathways involving Plasminogen Kringle 5 is essential for developing novel anti-angiogenic therapies and improving clinical outcomes in angiogenesis-related disorders.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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