Search
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Invitrogen
Plonmarlimab Humanized Recombinant Human Monoclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
产品信息
MA5-59681
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Human
/ IgG1
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
偶联物
形式
Lyophilized
浓度
1 mg/mL
纯化类型
Protein A
保存液
25mM histidine, pH 6.2, with 8% sucrose, 0.01% Tween 80
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Dry ice (international)
RRID
产品详细信息
For reconstitution, add sterile, distilled water to achieve a final antibody concentration of 1 mg/mL. Gently shake to solubilize the protein completely. Do not vortex. Reconstituted products should be stored at -80 °.
靶标信息
Plonmarlimab, also known as TJM2 or TJ003234, is a humanized IgG1 monoclonal antibody that targets and neutralizes granulocyte-macrophage colony-stimulating factor (GM-CSF), a cytokine implicated in inflammatory and autoimmune conditions. CSF2, also known as GM-CSF (Granulocyte-Macrophage Colony-Stimulating Factor), is located on chromosome 5q31. This gene encodes a cytokine that functions as a growth factor for hematopoietic progenitor cells, influencing the proliferation, differentiation, and survival of white blood cells such as granulocytes and macrophages. The CSF2 gene plays a critical role in the immune response by stimulating the production of granulocytes and macrophages from progenitor cells in the bone marrow, thus aiding in the defense against infections and in inflammatory responses. CSF2 is involved in various physiological processes and pathological conditions, including its overexpression in certain cancers and autoimmune diseases. The CSF2 receptor is a heterodimer composed of an alpha subunit (specific for GM-CSF) and a beta subunit shared with other cytokine receptors. Additionally, GM-CSF has been found to modulate inflammatory responses in the central nervous system, particularly influencing microglial cells and playing a role in neuroinflammatory and neurodegenerative disorders.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
