Invitrogen

Podocin Polyclonal Antibody

图: 1 / 1

Podocin Antibody (PA5-37904) in WB

Western blot analysis of Podocin using Podocin Polyclonal Antibody (Product # PA5-37904) (1 µg/mL) in staining of Human (A) and Mouse (B) Kidney lysate (35 µg protein in RIPA buffer). Detected by chemiluminescence.

Product Image Gallery

产品信息

PA5-37904

应用

建议稀释比

已发表文章

免疫印迹 (WB)

0.5-2 µg/mL

产品规格

种属反应

Human, Mouse

宿主/亚型

Goat / IgG

分类

Polyclonal

类型

Antibody

抗原

Peptide with sequence C-SPSKPVEPLNPKK, from the C-terminus of NPHS2

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Ammonium sulfate precipitation

保存液

TBS, pH 7.3, with 0.5% BSA

内含物

0.02% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Wet ice

RRID

AB_2554512

产品详细信息

This antibody is predicted to react with cow based on sequence homology.

This antibody is tested in Peptide ELISA: antibody detection limit dilution 64,000.

靶标信息

The pathological conditions of SRN1 correlate well with mutations at the NPHS2 gene, where expression of a protein known as Podocin occurs. Abnormal or inefficient signaling through Podocin protein-dependent networks contributes to the development of podocyte dysfunction and proteinuria. The human NPHS2 gene maps to chromosome 1q25-q31 and encodes a 383 amino acid protein. Podocin is an integral membrane protein that appears to fold into a hairpin-like structure with intracellular amino- and carboxy-termini. Transmembrane and cytoplasmic portions of Podocin share homology to the corresponding regions of the stomatin family proteins. Expression of high-order oligomers of Podocin in glomerular podocytes may reflect a scaffolding function that influences proper function of the glomerular filtration barrier, which is necessary for renal stability.

仅用于科研。不用于诊断过程。未经明确授权不得转售。