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Invitrogen
Podocin Recombinant Rabbit Monoclonal Antibody (2O10G3)
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Podocin Antibody (MA5-42776) in WB
Western blot was performed using Podocin Recombinant Rabbit Monoclonal Antibody (2O10G3) (Product # MA5-42776) and a ~45 kDa band corresponding to Podocin was observed in Mouse Kidney tissue. Whole cell extracts (30 µg lysate) of Mouse Kidney (Lane 1), Rat Kidney (Lane 2), Mouse Liver (Lane 3), Rat Liver (Lane 4), Mouse Skeletal Muscle (Lane 5), Rat Skeletal Muscle (Lane 6) were electrophoresed using NuPAGE™ 4-12% Bis-Tris Protein Gel (Product # NP0322BOX), 12 well. Resolved proteins were then transferred onto a nitrocellulose membrane (Pr... View More
产品信息
MA5-42776
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
2O10G3
抗原
Synthetic peptide
偶联物
形式
Liquid
浓度
1.2 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive test controls include: HeLa, HT-29, 293T.
Immunogen sequence: AQRQAKVRMI AAEAEKAASE SLRMAAEILS GTPAAVQLRY LHTLQSLSTE KPSTVVLPLP FDLLNCLSSP SNRTQGSLPF PSPSKPVEPL NPKKKDSPML
靶标信息
The pathological conditions of SRN1 correlate well with mutations at the NPHS2 gene, where expression of a protein known as Podocin occurs. Abnormal or inefficient signaling through Podocin protein-dependent networks contributes to the development of podocyte dysfunction and proteinuria. The human NPHS2 gene maps to chromosome 1q25-q31 and encodes a 383 amino acid protein. Podocin is an integral membrane protein that appears to fold into a hairpin-like structure with intracellular amino- and carboxy-termini. Transmembrane and cytoplasmic portions of Podocin share homology to the corresponding regions of the stomatin family proteins. Expression of high-order oligomers of Podocin in glomerular podocytes may reflect a scaffolding function that influences proper function of the glomerular filtration barrier, which is necessary for renal stability.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: nephrosis 2 homolog, podocin; nephrosis 2 idiopathic steroid-resistant (podocin); nephrosis 2, idiopathic, steroid-resistant (podocin); NPHS2 podocin; Podocin
基因别名: NPHS2; PDCN; podocin; SRN1
UniProt ID: (Human) Q9NP85, (Rat) Q8K4G9
Entrez Gene ID: (Human) 7827, (Rat) 170672
