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Invitrogen
PrP Monoclonal Antibody (2G11)
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产品信息
MA1-82828
应用
建议稀释比
已发表文章
产品规格
种属反应
Sheep
已发表种属
Bovine,
Rabbit
宿主/亚型
Mouse
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
2G11
抗原
Synthetic peptide corresponding to 146-R(154)R(171)-182 of ovine PrP
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein G
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody recognizes the scrapie-associated protease-resistant isoform (PrPsc) of ovine prion protein (PrP). The prion protein is encoded by the PrP gene and is constitutively expressed as the normal cellular isoform PrPc by many cell types. Clone 2G11 specifically recognizes the R151-R159 sequence and does not recognize the non-pathogenic PrPc form.
Pre-treat samples with trypsin at 37°C for 5 minutes followed by heat-mediated antigen retrieval using 10mM citrate buffer (pH6.0), followed by treatment of tissue sections in 98% formic acid for 30 minutes for optimal results.
靶标信息
Human prion protein (PrP), also known as PRNP, is a ubiquitously expressed GPI-anchored cell surface glycoprotein associating with lipid raft components and functioning as a signaling molecule. PrP plays a role in apoptosis in a cell context-dependent manner, is involved in proliferation of epithelial cells and in distribution of junction-associated proteins in human enterocytes. Conversion of this normal cellular prion protein (PrPc) into an abnormal conformer (PrPSc) is the crucial step associated with triggering the pathogenesis of the prion neurodegenerative disorders, such as the Creutzfeld-Jakob disease (CJD). Whereas PrPc is rich in alpha-helices, the PrPSc form has higher content of beta-sheets and is resistant to proteinase K.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: BSE; CD230; Major prion protein; MGC26679; PK resistant core; prion protein (p27-30) (Creutzfeldt-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia); PrP; PrPc; TSE
基因别名: PRNP; PRP; PRPC; SIP
UniProt ID: (Sheep) P23907
Entrez Gene ID: (Sheep) 493887
