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Invitrogen
Pravastatin Recombinant Mouse Monoclonal Antibody (2B4)
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Pravastatin Antibody (MA566359) in SDS-PAGE
SDS-PAGE characterization of Pravastatin under reducing conditions. Lane M: Protein marker (kDa); Lane PVT: Purified Pravastatin Recombinant Monoclonal (Product # MA566359). Pravastatin showing heavy chain (~50 kDa) and light chain (~25 kDa). Gels were stained with Coomassie Brilliant Blue R-665.
产品信息
MA566359
产品规格
种属反应
Chemical
宿主/亚型
Mouse
/ IgG
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
2B4
抗原
Conjugate of PVT hapten and KLH.
偶联物
形式
Liquid
浓度
2 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
0.09% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Pravastatin is a member of the statin class of medications, primarily used to lower cholesterol and prevent cardiovascular disease. It functions by inhibiting the enzyme HMG-CoA reductase, which plays a central role in the production of cholesterol in the liver. Pravastatin is unique among statins due to its hydrophilic nature, which affects its absorption and distribution in the body, making it less likely to penetrate extrahepatic tissues. The gene location for HMG-CoA reductase is on chromosome 5q13.3, and the enzyme is a key target for pravastatin's lipid-lowering effects. Pravastatin is often compared to other statins like pitavastatin in clinical trials to evaluate its efficacy in lipid management. It is available in various dosages, commonly 40 mg, and is used in combination therapies for enhanced lipid-lowering effects. The biosimilar market for pravastatin is influenced by regulatory policies and market strategies, which are crucial for its adoption and development.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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