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Invitrogen
Shiga toxin 1 (Pritoxaximab Biosimilar) Recombinant Human Monoclonal Antibody
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Shiga toxin 1 (Pritoxaximab Biosimilar) Antibody (MA5-41995) in SDS-PAGE
SDS-PAGE analysis of the recombinant Escherichia coli shiga toxin type 1 B subunit protein expressed in CHO cells using a Pritoxaximab biosimilar monoclonal antibody (Product # MA5-41995). R denotes the lane was run under reducing conditions. NR denotes the lane was run under non-reducing conditions.
产品信息
MA5-41995
产品规格
种属反应
Bacteria
宿主/亚型
Human
/ IgG1, kappa
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
抗原
Escherichia coli shiga toxin type 1 B subunit
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Endotoxin level < 0.01EU/µg by LAL method
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 °C for one week. Store at -20 to -80 °C for twelve months from the date of receipt.
靶标信息
Shiga toxin 1 (Stx1) is produced by certain strains of Shigella dysenteriae and Escherichia coli, including strains that cause severe gastrointestinal diseases such as dysentery and hemorrhagic colitis. Structurally, Stx1 is an AB5 toxin, composed of one enzymatically active A subunit and five identical B subunits. The A subunit contains the N-glycosidase enzyme that inactivates the 28S ribosomal RNA, thereby halting protein synthesis and leading to cell death. The B subunits form a pentameric ring that binds to the glycolipid receptor Gb3 (globotriaosylceramide) on the surface of host cells, facilitating the entry of the A subunit into the cell. Functionally, Stx1 is highly cytotoxic and contributes to the pathogenicity of bacterial strains that produce it, leading to serious conditions such as hemolytic uremic syndrome (HUS) characterized by kidney failure, hemolytic anemia, and thrombocytopenia.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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