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Invitrogen
Profilin 1 Polyclonal Antibody
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Product Details
PA5-17444
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Human,
Mouse,
Rat
Published species
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to human profilin-1
Conjugate
Form
Liquid
Concentration
78 µg/mL
Purification
Antigen affinity chromatography, Protein A
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
Profilin is an ubiquitous small (12-15 kDa) phosphoinositides and poly-L-proline binding protein that plays a role in both signal transduction pathways and actin filament dynamics. There are two mammalian profilins with similar biochemical properties but different expression patterns. Profilin I appears to be highly expressed in most tissues except for skeletal muscle. Profilin II is predominantly expressed in brain and at lower levels in skeletal muscle, uterus and kidney. Profilin is a mainly cytosolic protein with higher concentrations in dynamic membrane areas like the leading edge and ruffling membranes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: actin binding protein; Epididymis tissue protein Li 184a; Profilin I; Profilin-1
Gene Aliases: ALS18; Pfn; PFN1
UniProt ID: (Human) P07737, (Bovine) P02584, (Rat) P62963, (Mouse) P62962
Entrez Gene ID: (Human) 5216, (Bovine) 513895, (Rat) 64303, (Mouse) 18643
adenyl-nucleotide exchange factor activity
actin binding
actin monomer binding
receptor binding
protein binding
phosphatidylinositol-4,5-bisphosphate binding
Rho GTPase binding
poly(A) RNA binding
proline-rich region binding
cadherin binding involved in cell-cell adhesion
actin or actin-binding cytoskeletal protein
cytoskeletal protein
non-motor actin binding protein
neural tube closure
positive regulation of epithelial cell migration
actin cytoskeleton organization
negative regulation of actin filament polymerization
positive regulation of actin filament polymerization
negative regulation of actin filament bundle assembly
positive regulation of actin filament bundle assembly
positive regulation of ATPase activity
positive regulation of transcription from RNA polymerase II promoter
positive regulation of viral transcription
protein stabilization
positive regulation of DNA metabolic process
positive regulation of stress fiber assembly
negative regulation of stress fiber assembly
Wnt signaling pathway, planar cell polarity pathway
cellular response to growth factor stimulus
cell-cell adhesion
positive regulation of ruffle assembly
regulation of transcription from RNA polymerase II promoter
actin polymerization or depolymerization
response to organic substance
regulation of actin polymerization or depolymerization
sequestering of actin monomers
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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