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Invitrogen

Protein APC Polyclonal Antibody

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View all (30) Protein APC antibodies

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Protein APC Polyclonal Antibody

Product Details

PA5-30580

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human APC. The exact sequence is proprietary.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.44 mg/mL

Amount

144 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7, with 20% glycerol

Contains

0.025% ProClin 300

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2548054

Product Specific Information

Recommended positive controls: 293T, A431, HeLa, HepG2.

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: adenomatosis polyposis coli; adenomatosis polyposis coli tumor suppressor; adenomatous polyposis coli; adenomatous polyposis coli (APC); Adenomatous polyposis coli protein; APC; APC, WNT signaling pathway regulator; Deleted in polyposis 2.5; epididymis secretory sperm binding protein; FAP; FPC; multiple intestinal neoplasia; Protein APC; protein phosphatase 1, regulatory subunit 46; Unknown; unnamed protein product; WNT signaling pathway regulator

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Gene Aliases: AI047805; APC; AU020952; AW124434; BTPS2; CC1; DESMD; DP2; DP2.5; DP3; GS; mAPC; Min; PPP1R46; RATAPC

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UniProt ID: (Human) P25054, (Rat) P70478

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Entrez Gene ID: (Human) 324, (Mouse) 11789, (Rat) 24205

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Function(s)
protein binding beta-catenin binding microtubule binding protein kinase regulator activity protein kinase binding ubiquitin protein ligase binding macromolecular complex binding gamma-catenin binding cadherin binding microtubule plus-end binding dynein complex binding protease binding protein complex binding
Process(es)
mitotic cytokinesis kidney development hair follicle development protein complex assembly cellular response to DNA damage stimulus negative regulation of microtubule depolymerization cell cycle arrest metaphase/anaphase transition of mitotic cell cycle mitotic spindle assembly checkpoint establishment or maintenance of cell polarity pattern specification process axonogenesis negative regulation of cell proliferation axis specification anterior/posterior pattern specification dorsal/ventral pattern formation proximal/distal pattern formation Wnt signaling pathway cell migration stem cell population maintenance negative regulation of Wnt signaling pathway regulation of cell migration positive regulation of cell migration regulation of epithelial cell differentiation positive regulation of epithelial cell differentiation positive regulation of microtubule polymerization cytoplasmic microtubule organization neuron projection development positive regulation of pseudopodium assembly regulation of microtubule-based process T cell differentiation in thymus somatic stem cell population maintenance negative regulation of odontogenesis positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of MAPK cascade skin development canonical Wnt signaling pathway involved in negative regulation of apoptotic process canonical Wnt signaling pathway involved in positive regulation of apoptotic process regulation of cell differentiation positive regulation of cell differentiation regulation of osteoblast differentiation regulation of osteoclast differentiation positive regulation of protein catabolic process negative regulation of cyclin-dependent protein serine/threonine kinase activity positive regulation of cell adhesion muscle cell cellular homeostasis thymus development negative regulation of epithelial cell proliferation regulation of nitrogen compound metabolic process chromosome organization regulation of cell cycle positive regulation of cell division regulation of attachment of spindle microtubules to kinetochore retina development in camera-type eye canonical Wnt signaling pathway negative regulation of epithelial cell proliferation involved in prostate gland development negative regulation of canonical Wnt signaling pathway regulation of glutamate metabolic process cell fate specification heart valve development endocardial cushion morphogenesis cell adhesion nervous system development insulin receptor signaling pathway proteasome-mediated ubiquitin-dependent protein catabolic process regulation of microtubule-based movement protein-containing complex assembly bicellular tight junction assembly regulation of primary metabolic process positive regulation of cold-induced thermogenesis negative regulation of cell cycle G1/S phase transition positive regulation of protein localization to centrosome negative regulation of G1/S transition of mitotic cell cycle pancreas development response to drug response to alcohol cellular response to nerve growth factor stimulus
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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