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Invitrogen
Protein APC Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-86107
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide, corresponding to the C-terminal of Human APC.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Purity is > 95% by SDS-PAGE.
靶标信息
This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: adenomatosis polyposis coli; Adenomatous polyposis coli protein; Deleted in polyposis 2.5; FAP; FPC; multiple intestinal neoplasia; Protein APC
基因别名: AI047805; APC; AU020952; AW124434; CC1; DP2.5; mAPC; Min; RATAPC
UniProt ID: (Rat) P70478
Entrez Gene ID: (Mouse) 11789, (Rat) 24205
mitotic cytokinesis
kidney development
hair follicle development
protein complex assembly
cellular response to DNA damage stimulus
negative regulation of microtubule depolymerization
cell cycle arrest
metaphase/anaphase transition of mitotic cell cycle
mitotic spindle assembly checkpoint
establishment or maintenance of cell polarity
pattern specification process
axonogenesis
negative regulation of cell proliferation
axis specification
anterior/posterior pattern specification
dorsal/ventral pattern formation
proximal/distal pattern formation
Wnt signaling pathway
cell migration
stem cell population maintenance
negative regulation of Wnt signaling pathway
regulation of cell migration
positive regulation of cell migration
regulation of epithelial cell differentiation
positive regulation of epithelial cell differentiation
positive regulation of microtubule polymerization
cytoplasmic microtubule organization
neuron projection development
positive regulation of pseudopodium assembly
regulation of microtubule-based process
T cell differentiation in thymus
somatic stem cell population maintenance
negative regulation of odontogenesis
positive regulation of apoptotic process
negative regulation of apoptotic process
negative regulation of MAPK cascade
skin development
canonical Wnt signaling pathway involved in negative regulation of apoptotic process
canonical Wnt signaling pathway involved in positive regulation of apoptotic process
regulation of cell differentiation
positive regulation of cell differentiation
regulation of osteoblast differentiation
regulation of osteoclast differentiation
positive regulation of protein catabolic process
negative regulation of cyclin-dependent protein serine/threonine kinase activity
positive regulation of cell adhesion
muscle cell cellular homeostasis
thymus development
negative regulation of epithelial cell proliferation
regulation of nitrogen compound metabolic process
chromosome organization
regulation of cell cycle
positive regulation of cell division
regulation of attachment of spindle microtubules to kinetochore
retina development in camera-type eye
canonical Wnt signaling pathway
negative regulation of epithelial cell proliferation involved in prostate gland development
negative regulation of canonical Wnt signaling pathway
regulation of glutamate metabolic process
pancreas development
response to drug
response to alcohol
cellular response to nerve growth factor stimulus
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