Search
Invitrogen
Protein APC Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
产品信息
PA5-86270
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide, corresponding to amino acids 2020-2070 of Human APC.
偶联物
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Purity is > 95% by SDS-PAGE.
靶标信息
This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: adenomatosis polyposis coli; adenomatosis polyposis coli tumor suppressor; adenomatous polyposis coli; adenomatous polyposis coli (APC); Adenomatous polyposis coli protein; APC; APC, WNT signaling pathway regulator; Deleted in polyposis 2.5; epididymis secretory sperm binding protein; FAP; FPC; multiple intestinal neoplasia; Protein APC; protein phosphatase 1, regulatory subunit 46; Unknown; unnamed protein product; WNT signaling pathway regulator
基因别名: AI047805; APC; AU020952; AW124434; BTPS2; CC1; DESMD; DP2; DP2.5; DP3; GS; mAPC; Min; PPP1R46; RATAPC
UniProt ID: (Human) P25054, (Rat) P70478
Entrez Gene ID: (Human) 324, (Mouse) 11789, (Rat) 24205
protein binding
beta-catenin binding
microtubule binding
protein kinase regulator activity
protein kinase binding
ubiquitin protein ligase binding
macromolecular complex binding
gamma-catenin binding
cadherin binding
microtubule plus-end binding
dynein complex binding
protease binding
protein complex binding
mitotic cytokinesis
kidney development
hair follicle development
protein complex assembly
cellular response to DNA damage stimulus
negative regulation of microtubule depolymerization
cell cycle arrest
metaphase/anaphase transition of mitotic cell cycle
mitotic spindle assembly checkpoint
establishment or maintenance of cell polarity
pattern specification process
axonogenesis
negative regulation of cell proliferation
axis specification
anterior/posterior pattern specification
dorsal/ventral pattern formation
proximal/distal pattern formation
Wnt signaling pathway
cell migration
stem cell population maintenance
negative regulation of Wnt signaling pathway
regulation of cell migration
positive regulation of cell migration
regulation of epithelial cell differentiation
positive regulation of epithelial cell differentiation
positive regulation of microtubule polymerization
cytoplasmic microtubule organization
neuron projection development
positive regulation of pseudopodium assembly
regulation of microtubule-based process
T cell differentiation in thymus
somatic stem cell population maintenance
negative regulation of odontogenesis
positive regulation of apoptotic process
negative regulation of apoptotic process
negative regulation of MAPK cascade
skin development
canonical Wnt signaling pathway involved in negative regulation of apoptotic process
canonical Wnt signaling pathway involved in positive regulation of apoptotic process
regulation of cell differentiation
positive regulation of cell differentiation
regulation of osteoblast differentiation
regulation of osteoclast differentiation
positive regulation of protein catabolic process
negative regulation of cyclin-dependent protein serine/threonine kinase activity
positive regulation of cell adhesion
muscle cell cellular homeostasis
thymus development
negative regulation of epithelial cell proliferation
regulation of nitrogen compound metabolic process
chromosome organization
regulation of cell cycle
positive regulation of cell division
regulation of attachment of spindle microtubules to kinetochore
retina development in camera-type eye
canonical Wnt signaling pathway
negative regulation of epithelial cell proliferation involved in prostate gland development
negative regulation of canonical Wnt signaling pathway
regulation of glutamate metabolic process
cell fate specification
heart valve development
endocardial cushion morphogenesis
cell adhesion
nervous system development
insulin receptor signaling pathway
proteasome-mediated ubiquitin-dependent protein catabolic process
regulation of microtubule-based movement
protein-containing complex assembly
bicellular tight junction assembly
regulation of primary metabolic process
positive regulation of cold-induced thermogenesis
negative regulation of cell cycle G1/S phase transition
positive regulation of protein localization to centrosome
negative regulation of G1/S transition of mitotic cell cycle
pancreas development
response to drug
response to alcohol
cellular response to nerve growth factor stimulus
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
