Invitrogen

Protein APC Recombinant Rabbit Monoclonal Antibody (SC61-03)

查看其他27个Protein APC抗体

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

说明书
实验方案
问题与答案
技术支持
说明书
实验方案
问题与答案
技术支持
说明书
实验方案
问题与答案
技术支持
Protein APC Recombinant Rabbit Monoclonal Antibody (SC61-03)

产品信息

MA5-41163

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:5,000-1:20,000
-

免疫组化（石蜡） (IHC (P))

1:200-1:1000
-

免疫组化（冰冻） (IHC (F))

1:500
-
产品规格

种属反应

Human, Mouse

宿主/亚型

Rabbit / IgG

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

SC61-03

抗原

Synthetic peptide within human apc aa 51-100 / 2843.
查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

TBS, pH 7.4, with 0.05% BSA, 40% glycerol

内含物

0.05% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2898917

靶标信息

This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

篇参考文献 (0)

您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
引用该产品

生物信息学

蛋白别名: adenomatosis polyposis coli tumor suppressor; Adenomatous polyposis coli protein; Deleted in polyposis 2.5; FAP; FPC; multiple intestinal neoplasia; Protein APC; protein phosphatase 1, regulatory subunit 46; truncated adenomatosis polyposis coli; WNT signaling pathway regulator

查看更多 收起

基因别名: AI047805; APC; AU020952; AW124434; BTPS2; CC1; DP2; DP2.5; DP3; GS; mAPC; Min; PPP1R46

查看更多 收起

UniProt ID: (Human) P25054

查看更多 收起

Entrez Gene ID: (Human) 324, (Mouse) 11789

查看更多 收起

功能
protein binding beta-catenin binding microtubule binding protein kinase regulator activity protein kinase binding protein complex binding gamma-catenin binding cadherin binding microtubule plus-end binding protease binding
参与通路
mitotic cytokinesis kidney development hair follicle development protein complex assembly cellular response to DNA damage stimulus negative regulation of microtubule depolymerization cell cycle arrest metaphase/anaphase transition of mitotic cell cycle mitotic spindle assembly checkpoint establishment or maintenance of cell polarity pattern specification process axonogenesis negative regulation of cell proliferation axis specification anterior/posterior pattern specification dorsal/ventral pattern formation proximal/distal pattern formation Wnt signaling pathway cell migration stem cell population maintenance negative regulation of Wnt signaling pathway regulation of cell migration positive regulation of cell migration regulation of epithelial cell differentiation positive regulation of epithelial cell differentiation positive regulation of microtubule polymerization cytoplasmic microtubule organization neuron projection development positive regulation of pseudopodium assembly regulation of microtubule-based process T cell differentiation in thymus somatic stem cell population maintenance negative regulation of odontogenesis positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of MAPK cascade skin development canonical Wnt signaling pathway involved in negative regulation of apoptotic process canonical Wnt signaling pathway involved in positive regulation of apoptotic process regulation of cell differentiation positive regulation of cell differentiation regulation of osteoblast differentiation regulation of osteoclast differentiation positive regulation of protein catabolic process negative regulation of cyclin-dependent protein serine/threonine kinase activity positive regulation of cell adhesion muscle cell cellular homeostasis thymus development negative regulation of epithelial cell proliferation regulation of nitrogen compound metabolic process chromosome organization regulation of cell cycle positive regulation of cell division regulation of attachment of spindle microtubules to kinetochore retina development in camera-type eye canonical Wnt signaling pathway negative regulation of epithelial cell proliferation involved in prostate gland development negative regulation of canonical Wnt signaling pathway regulation of glutamate metabolic process cell fate specification cellular component disassembly involved in execution phase of apoptosis cell adhesion pancreas development response to drug proteasome-mediated ubiquitin-dependent protein catabolic process bicellular tight junction assembly response to alcohol beta-catenin destruction complex assembly beta-catenin destruction complex disassembly cellular response to nerve growth factor stimulus
guarantee_icon

性能保障

只要您发现Invitrogen抗体在实验中的表现与网站或说明书的所述内容不符，您即可享受免费退换货服务。*

了解更多
help_icon

随时为您服务

获取常见问题的专家解答，或者直接联系我们的技术专家，咨询应用、设备、常规产品使用问题。

联系技术支持