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Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
A BLAST analysis was used to suggest cross-reactivity with rat, human, and mouse based on 100% sequence homology. Cross-reactivity with Protein Kinase C delta-Binding Protein from other sources has not been determined.
JAB-1 is a 38 kDa protein which was originally described as a coactivator for cJUN. It is present in a large protein complex called the "Signalosome", which has been proposed to play a signaling role in mammalian cells. This protein complex appears to be analogous to the COP9 complex in plants, which is important in light-mediated plant development. Although the specific function of JAB-1 in this complex is unclear, it has recently been implicated in targeting proteins for degradation by the proteasome.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Caveolae-associated protein 3; Cavin-3; hSRBC; MGC20400; Protein kinase C delta-binding protein; protein kinase C, delta binding protein; sdr-related gene product that binds to c-kinase; Serum deprivation response factor-related gene product that binds to C-kinase
基因别名: cavin-3; CAVIN3; HSRBC; PRKCDBP; SRBC
UniProt ID: (Human) Q969G5
Entrez Gene ID: (Human) 112464