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Invitrogen
Prothrombin Recombinant Rabbit Monoclonal Antibody (9A1)
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Prothrombin Antibody (MA5-49853) in IHC (P)
Immunohistochemistry analysis with a Prothrombin monoclonal antibody (Product # MA5-49853) using a dilution of 1:100 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30 min at RT. Then primary antibody (1% BSA) was ... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-49853
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
9A1
抗原
A synthesized peptide derived from human Prothrombin
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1.25 mg/mL
规格
125 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C or -80°C if preferred
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
Prothrombin or Coagulation factor II, is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Coagulation factor II; prepro-coagulation factor II; Prothrombin; prothrombin B-chain; thrombin factor II; thrombin precursor; unnamed protein product
基因别名: F2; PT; RPRGL2; THPH1
UniProt ID: (Human) P00734
Entrez Gene ID: (Human) 2147
lipopolysaccharide binding
endopeptidase activity
serine-type endopeptidase activity
receptor binding
calcium ion binding
protein binding
growth factor activity
heparin binding
peptidase activity
serine-type peptidase activity
hydrolase activity
receptor agonist activity
thrombospondin receptor activity
proteolysis
acute-phase response
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
blood coagulation
hemostasis
positive regulation of cell proliferation
regulation of cell shape
response to wounding
regulation of gene expression
negative regulation of platelet activation
platelet activation
regulation of blood coagulation
positive regulation of blood coagulation
negative regulation of blood coagulation
positive regulation of cell growth
positive regulation of insulin secretion
positive regulation of collagen biosynthetic process
fibrinolysis
negative regulation of proteolysis
positive regulation of JAK-STAT cascade
negative regulation of astrocyte differentiation
regulation of body fluid levels
positive regulation of release of sequestered calcium ion into cytosol
regulation of cytosolic calcium ion concentration
cytolysis by host of symbiont cells
positive regulation of protein kinase B signaling
negative regulation of fibrinolysis
antimicrobial humoral immune response mediated by antimicrobial peptide
thrombin receptor signaling pathway
neutrophil mediated killing of gram-negative bacterium
negative regulation of cytokine production involved in inflammatory response
positive regulation of protein localization to nucleus
positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway
ligand-gated ion channel signaling pathway
positive regulation of reactive oxygen species metabolic process
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