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The protocadherin gamma gene cluster is one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: 3' RACE product; Pan-Gamma-Protocadherin-A; PCDH gamma A; PCDH-gamma-A; PCDH-gamma-A4; PCDHGA; pcdhga4; protocadherin 13; protocadherin 2; protocadherin gamma a1; protocadherin gamma A12; protocadherin gamma a2; protocadherin gamma B2; protocadherin gamma B6; protocadherin gamma b7; protocadherin gamma C-VI; protocadherin gamma c5; protocadherin gamma subfamily A, 10; protocadherin gamma subfamily A, 12; protocadherin gamma subfamily A, 3; protocadherin gamma subfamily A, 4; protocadherin gamma subfamily B, 5; protocadherin gamma subfamily B, 7; protocadherin gamma subfamily C, 3; protocadherin gamma-A1; protocadherin gamma-A10; protocadherin gamma-A11; protocadherin gamma-A12; protocadherin gamma-A2; protocadherin gamma-A3; Protocadherin gamma-A4; protocadherin gamma-A5; protocadherin gamma-A6; protocadherin gamma-A6-like; protocadherin gamma-A7; protocadherin gamma-A8; protocadherin gamma-A9; protocadherin gamma-B1; protocadherin gamma-B2; protocadherin gamma-B4; protocadherin gamma-B4-like; protocadherin gamma-B5; protocadherin gamma-B6; protocadherin gamma-B6-like; protocadherin gamma-B7; protocadherin gamma-C3; protocadherin gamma-C4; protocadherin gamma-C5
基因别名: mKIAA0588; mKIAA4054; pc2c; PC43; Pcdh13; Pcdh2; Pcdhga10temp; Pcdhga3; Pcdhga4; PCDHGB4; PCDHGB5; Pcdhgb7
UniProt ID: (Mouse) Q91XY4
Entrez Gene ID: (Rat) 102552497, (Rat) 102552705, (Rat) 102552796, (Rat) 553129, (Mouse) 93709, (Rat) 498849, (Mouse) 93722, (Rat) 252897, (Mouse) 93723, (Rat) 498850, (Mouse) 93724, (Mouse) 93710, (Rat) 498846, (Mouse) 93711, (Rat) 498847, (Mouse) 93712, (Rat) 252894, (Mouse) 93713, (Rat) 291637, (Mouse) 93714, (Mouse) 93715, (Rat) 291635, (Rat) 364843, (Mouse) 93716, (Rat) 252895, (Mouse) 93717, (Mouse) 93699, (Mouse) 93700, (Mouse) 93701, (Mouse) 93702, (Rat) 680448, (Mouse) 93703, (Mouse) 93704, (Rat) 364844, (Mouse) 93706, (Rat) 116782, (Mouse) 93707, (Mouse) 93708, (Rat) 641525