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The protocadherin gamma gene cluster is one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: 3' RACE product; Pan-Gamma-Protocadherin-A; PCDH gamma A; PCDH-gamma-A; PCDH-gamma-A4; PCDH-gammaC3; pcdh6; PCDHGA; PCDHGA1; PCDHGA10; PCDHGA11; PCDHGA12; PCDHGA2; PCDHGA3; PCDHGA5; PCDHGA7; PCDHGA8; PCDHGA9; PCDHGC3; protocadherin 13; protocadherin 2; protocadherin gamma a1; protocadherin gamma A12; protocadherin gamma a2; protocadherin gamma B2; protocadherin gamma B6; protocadherin gamma b7; protocadherin gamma C-VI; protocadherin gamma c5; protocadherin gamma family member; protocadherin gamma subfamily A, 10; protocadherin gamma subfamily A, 3; protocadherin gamma subfamily B, 7; protocadherin gamma-A6; unnamed protein product
基因别名: mKIAA0588; mKIAA4054; pc2c; PC43; Pcdh13; Pcdh2; Pcdhga10temp; Pcdhga3; PCDHGB4; PCDHGB5; Pcdhgb7
UniProt ID: (Mouse) Q91XY4
Entrez Gene ID: (Mouse) 93709, (Rat) 553129, (Rat) 498849, (Mouse) 93722, (Mouse) 93723, (Rat) 252897, (Mouse) 93724, (Rat) 498850, (Rat) 498846, (Mouse) 93710, (Mouse) 93711, (Rat) 498847, (Mouse) 93712, (Rat) 252894, (Rat) 291637, (Mouse) 93713, (Mouse) 93714, (Rat) 291635, (Mouse) 93715, (Mouse) 93716, (Rat) 364843, (Mouse) 93717, (Rat) 252895, (Mouse) 93699, (Rat) 680361, (Mouse) 93700, (Mouse) 93701, (Mouse) 93702, (Mouse) 93703, (Rat) 364844, (Mouse) 93704, (Rat) 116782, (Mouse) 93706, (Mouse) 93707, (Mouse) 93708, (Rat) 641525