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Invitrogen
Protogenin Polyclonal Antibody
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FIGURE: 1 / 1
Protogenin Antibody (PA5-47874) in IHC (F)
Immunohistochemical analysis of Protogenin in immersion fixed frozen sections of mouse embryo (E9.5). Samples were incubated with Protogenin polyclonal antibody (Product # PA5-47874) using a dilution of 10 µg/mL overnight at 4 °C followed by NorthernLights™ 493-conjugated Anti-Sheep IgG Secondary Antibody (green) and counterstained with DAPI (blue). Specific staining was localized to nuclei in the neural tu... View More
Product Details
PA5-47874
Product Specifications
Species Reactivity
Human
Host/Isotype
Sheep
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Mouse myeloma cell line NS0-derived recombinant human Protegenin Phe36-Ala952
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
In direct ELISAs, approximately 30% cross-reactivity with recombinant mouse Protegenin is observed.
Reconstitute in sterile PBS to a final concentration of 0.2 mg/mL.
Target Information
Protogenin, encoded by the PRTG gene, is a cell surface protein that belongs to the immunoglobulin superfamily and plays a critical role in neural development. Protogenin is involved in cell adhesion and signaling pathways that regulate processes such as neurogenesis, neuronal migration, and the establishment of neural circuits during embryonic development. Its expression is predominantly observed in the developing nervous system, where it facilitates interactions between cells and the extracellular matrix, contributing to the proper formation of brain structures. Protogenin's function in regulating cellular communication is essential for maintaining the balance between stem cell renewal and differentiation in neural tissues. Dysregulation or mutations in the PRTG gene can lead to developmental abnormalities and have been investigated for their potential connections to neurodevelopmental disorders. Research continues to explore protogenin's mechanisms and interaction networks to better understand its contributions to neural development and its potential as a therapeutic target in developmental disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: immunoglobulin superfamily, DCC subclass, member 5; Protein Shen-Dan; Protogenin; protogenin homolog (Gallus gallus); shen-dan
Gene Aliases: IGDCC5; PRTG
UniProt ID: (Human) Q2VWP7
Entrez Gene ID: (Human) 283659
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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