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HLA-DR Monoclonal Antibody (TU36), Qdot™ 655
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FIGURE: 1 / 3
HLA-DR Antibody (Q22158) in Flow
Histogram of gated human lymphocytes labeled with HLA-DR Mouse Anti-Human mAb (clone Tu36), Qdot® 655 Conjugate. Sample was acquired and analyzed using 405 nm excitation and a 660/20 band pass emission filter using a BD LSR II flow cytometer (BD Biosciences, San Jose, CA).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
Q22158
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
TU36
Immunogen
Human HLA-DR
Conjugate
Qdot™ 655
Qdot™ 655
Qdot™ 655
Excitation/Emission Max
300/654 nm
View spectra
Form
Liquid
Purification
purified
Storage buffer
0.05M borate, pH 8.3, with 1M betaine
Contains
0.05% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
HLA-DR, like other MHC class II molecules, is a transmembrane glycoprotein composed of a 36 kDa alpha chain (DRA) and 27 kDa beta chain (DRB). The alpha chain gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. HLA-DR is expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells and activated T lymphocytes. Three loci, DR, DQ and DP, encode the major expressed products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides, present them to T-helper cells, and have a critical role in the initiation of the immune response.
HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD74; CD74 antigen; CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated); CD74 molecule, major histocompatibility complex, class II invariant chain; class II MHC-associated invariant chain peptide; DASS-397D15.1; FLJ51114; FLJ75017; FLJ76359; gamma chain of class II antigens; HLA class II histocompatibility antigen gamma chain; HLA-DR antigens-associated invariant chain; HLA-DR-gamma; Ia antigen-associated invariant chain; Ia-associated invariant chain; Ii; MHC HLA-DR gamma chain; unnamed protein product; XXbac-BPG161M6.1
Gene Aliases: CD74; CLIP; DHLAG; HLADG; Ia-GAMMA; II; p33
Entrez Gene ID: (Human) 972
beta-amyloid binding
cytokine receptor activity
protein binding
cytokine binding
MHC class II protein complex binding
macrophage migration inhibitory factor binding
MHC class II protein binding
CD4 receptor binding
MHC class II protein binding, via antigen binding groove
identical protein binding
protein binding involved in protein folding
nitric-oxide synthase binding
prostaglandin biosynthetic process
positive regulation of cytokine-mediated signaling pathway
T cell activation involved in immune response
positive regulation of dendritic cell antigen processing and presentation
negative regulation of peptide secretion
positive regulation of type 2 immune response
negative regulation of mature B cell apoptotic process
protein folding
intracellular protein transport
immune response
positive regulation of gene expression
immunoglobulin mediated immune response
antigen processing and presentation
antigen processing and presentation of endogenous antigen
negative regulation of cell migration
positive regulation of B cell proliferation
positive regulation of prostaglandin biosynthetic process
positive regulation of chemokine production
positive regulation of interleukin-6 production
positive regulation of interleukin-8 production
response to interferon-gamma
macrophage migration inhibitory factor signaling pathway
regulation of macrophage activation
negative regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of MAPK cascade
negative regulation of DNA damage response, signal transduction by p53 class mediator
T cell selection
positive regulation of monocyte differentiation
negative regulation of viral entry into host cell
positive regulation of fibroblast proliferation
protein stabilization
positive regulation of macrophage cytokine production
protein-containing complex assembly
protein trimerization
positive regulation of ERK1 and ERK2 cascade
positive regulation of neutrophil chemotaxis
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
positive regulation of chemokine (C-X-C motif) ligand 2 production
positive regulation of macrophage migration inhibitory factor signaling pathway
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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