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Invitrogen
QKI-5 Recombinant Mouse Monoclonal Antibody (PSH10-22)
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QKI-5 Antibody (MA570046) in IHC (P)
Immunohistochemistry analysis of QKI-5 in paraffin-embedded mouse cerebellum tissue. Samples were incubated with QKI-5 monoclonal antibody (Product # MA570046) using a dilution of 1:20,000 for 1 hour at room temperature. The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 20 minutes. The tissues were blocked in 1% BSA for 20 minutes at room temperature, washe... View More
产品信息
MA570046
应用
建议稀释比
已发表文章
产品规格
种属反应
Cynomolgus monkey,
Human,
Mouse,
Pig,
Rat
宿主/亚型
Mouse
/ IgG1
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
PSH10-22
抗原
Synthetic peptide within human QKI-5 aa 301-341.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4, with 0.1% BSA, 40% glycerol
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Positive control: K-562 cell lysate, HeLa cell lysate, Mouse cerebellum tissue lysate, rat cerebellum tissue.
Subcellular location: Nucleus, Cytoplasm.
靶标信息
The QKI gene, also known as Quaking, encodes an RNA-binding protein that plays a critical role in myelination, as it is predominantly expressed in oligodendrocytes and Schwann cells. The QKI protein is involved in the regulation of mRNA stability, splicing, and export, which influences the development and differentiation of the nervous system. The QKI gene produces several isoforms, including QKI-5, QKI-6, and QKI-7, each having distinct functions and expression patterns. QKI-5, one of the major isoforms, is primarily located in the nucleus where it regulates RNA processing events essential for cell development and function. Mutations or dysregulation of the QKI gene have been implicated in various neurological disorders, including schizophrenia and myelin-related diseases such as multiple sclerosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: homolog of mouse quaking QKI (KH domain RNA binding protein); Hqk; KH domain-containing RNA-binding protein QKI; lethal, Chr 17, U Wisconsin 1; MqkI; PqkI; Protein quaking; protein quaking-like; QKI, KH domain containing, RNA binding; QKI, KH domain containing, RNA binding tv1; QKI-5 protein; quaking homolog, KH domain RNA binding; quaking protein; RNA binding protein HQK
基因别名: 1110003F05Rik; 1500005P18; HKQ; Hqk; hqkI; l(17)-1Wis; l17Wis1; PqkI; QK; QK1; QK3; QKI
UniProt ID: (Pig) Q5W9D5, (Human) Q96PU8, (Mouse) Q9QYS9
Entrez Gene ID: (Pig) 492277, (Human) 9444, (Cynomolgus monkey) 102126515, (Mouse) 19317, (Rat) 100910212
vasculogenesis
mRNA processing
spermatid development
RNA splicing
positive regulation of gene expression
myelination
muscle cell differentiation
long-chain fatty acid biosynthetic process
mRNA transport
3'-UTR-mediated mRNA destabilization
regulation of translation
transport
multicellular organism development
axon ensheathment
cell differentiation
