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A 1:1,000 dilution of MA5-45969 was sufficient for detection of RAB3D in 10 µg of A549, T-47D cells, mouse and rat brain, kidney by ECL immunoblot analysis using Goat Anti-Mouse IgG:HRP as the secondary antibody.|Detects approximately 24 kDa. Does not show cross reactivity to RAB3A, RAB3B, or RAB3C.
Rab proteins are low-molecular-weight GTP-binding proteins that form the largest branch of the Ras superfamily of GTPases. Located on the cytoplasmic face of organelles and vesicles, rab proteins are involved in intracellular membrane fusion reactions. Three membrane proteins, synaptosomal associated protein of 25 kDa (SNAP-25), synaptobrevin, and syntaxin, form the core of a ubiquitous membrane fusion machine that interacts with the soluble proteins N-ethylmaleimide-sensitive factor (NSF) and a-SNAP. Rab proteins, in coordination with the core fusion machinery and Munc-18, help to mediate vesicle docking and fusion. There exist over 40 rab proteins that have been described in mammals. Rab 3D has been shown to be present, in part, in the tongue, pancreas, and liver.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: glioblastoma overexpressed; GTP-binding protein Rab-3D; Rab3D upregulated with myeloid differentiation; Ras-related protein Rab-3D
基因别名: C130057E11Rik; D2-2; GOV; RAB16; RAB3D; RAD3D
UniProt ID: (Human) O95716, (Mouse) P35276, (Rat) Q63942
Entrez Gene ID: (Human) 9545, (Mouse) 19340, (Rat) 140665