Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
产品信息
PA1-9091
产品规格
种属反应
Human
已发表种属
Rat
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to the C terminus amino acids PQPTRQQKRACSLL.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Ammonium sulfate precipitation
保存液
TBS, pH 7.3, with 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2176141
产品详细信息
This antibody is predicted to react with mouse and rat based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 32,000.
靶标信息
RAC, a small GTPase in the ras family, regulates the formation of membrane ruffles, lamellipodia and filopodia. It is involved in cytoskeletal actin organization and transformation. The p21 activated kinases (PAKs) are direct targets of active Rac and Cdc42 which can induce the assembly of polarized cytoskeletal structures when expressed in fibroblasts. RAC1 and RAC2 are also essential components of NADPH oxidase, the enzyme responsible for generating free radicals.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: GX; p21-Rac2; Ras-related C3 botulinum toxin substrate 2; Ras-related C3 botulinum toxin substrate 3 (rho family, small GTP-binding protein Rac2); Small G protein
基因别名: EN-7; Gx; HSPC022; p21-Rac2; RAC2
UniProt ID: (Human) P15153
Entrez Gene ID: (Human) 5880
chemotaxis
actin filament organization
signal transduction
G-protein coupled receptor signaling pathway
small GTPase mediated signal transduction
positive regulation of cell proliferation
regulation of hydrogen peroxide metabolic process
positive regulation of lamellipodium assembly
regulation of cell-substrate adhesion
cell projection assembly
platelet activation
regulation of T cell proliferation
regulation of mast cell degranulation
bone resorption
regulation of protein kinase activity
regulation of small GTPase mediated signal transduction
regulation of respiratory burst
regulation of mast cell chemotaxis
lymphocyte aggregation
positive regulation of neutrophil chemotaxis
regulation of neutrophil migration
positive regulation of protein targeting to mitochondrion
