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Positive Samples: HL-60; Cellular Location: Cytoplasm
Immunogen sequence: MQAIKCVVVG DGAVGKTCLL ISYTTNAFPG EYIPTVFDNY SANVMVDSKP VNLGLWDTAG QEDYDRLRPL SYPQTDVFLI CFSLVSPASY ENVRAKWFPE VRHHCPSTPI ILVGTKLDLR DDKDTIEKLK EKKLAPITYP QGLALAKEID SVKYLECSAL TQRGLKTVFD EAIRAVLCPQ PTRQQKRACS LL
RAC, a small GTPase in the ras family, regulates the formation of membrane ruffles, lamellipodia and filopodia. It is involved in cytoskeletal actin organization and transformation. The p21 activated kinases (PAKs) are direct targets of active Rac and Cdc42 which can induce the assembly of polarized cytoskeletal structures when expressed in fibroblasts. RAC1 and RAC2 are also essential components of NADPH oxidase, the enzyme responsible for generating free radicals.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: EN-7 protein; GX; p21-Rac2; Protein EN-7; RAS-related C3 botulinum substrate 2; Ras-related C3 botulinum toxin substrate 2; Ras-related C3 botulinum toxin substrate 3 (rho family, small GTP-binding protein Rac2); Small G protein
基因别名: AI323801; AI452260; EN-7; Gx; HSPC022; p21-Rac2; RAC2
UniProt ID: (Human) P15153, (Mouse) Q05144
Entrez Gene ID: (Human) 5880, (Rat) 366957, (Mouse) 19354