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Invitrogen
RAD50 Recombinant Rabbit Monoclonal Antibody (K01_2P20)
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RAD50 Antibody (MA564185) in IHC (P)
Immunohistochemistry (Paraffin) analysis of RAD50 in paraffin-embedded Human Cholangiocarcinoma. Samples were incubated with RAD50 recombinant monoclonal (Product # MA564185). High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.
产品信息
MA564185
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293F
分类
Recombinant Monoclonal
类型
Antibody
克隆号
K01_2P20
抗原
Recombinant protein of human Rad50 (aa 1-425).
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A/G
保存液
50mM tris glycine, pH 7.4, with 150mM NaCl, 40% glycerol, 0.05% BSA
内含物
0.01% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: MSRIEKMSIL GVRSFGIEDK DKQIITFFSP LTILVGPNGA GKTTIIECLK YICTGDFPPG TKGNTFVHDP KVAQETDVRA QIRLQFRDVN GELIAVQRSM VCTQKSKKTE FKTLEGVITR TKHGEKVSLS SKCAEIDREM ISSLGVSKAV LNNVIFCHQE DSNWPLSEGK ALKQKFDEIF SATRYIKALE TLRQVRQTQG QKVKEYQMEL KYLKQYKEKA CEIRDQITSK EAQLTSSKEI VKSYENELDP LKNRLKEIEH NLSKIMKLDN EIKALDSRKK QMEKDNSELE EKMEKVFQGT DEQLNDLYHN HQRTVREKER KLVDCHRELE KLNKESRLLN QEKSELLVEQ GRLQLQADRH QEHIRARDSL IQSLATQLEL DGFERGPFSE RQIKNFHKLV RERQEGEAKT ANQLMNDFAE KETLK
Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 91%, Pig - 95%, Cynomolgus monkey - 100%.
靶标信息
Rad50-13B3 recognizes human Rad50, a 153a protein involved in DNA double strand break repair. Rad50 is associated with Mre11 and p95 (Nibrin) to form a multiprotein complex involved in the double strand break repair process. Upon DNA damage, Rad50 and Mre11 redistribute and are co-localized within the nucleus of damaged cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DNA repair protein RAD50; hRAD50; hsRAD50; RAD50 2; RAD50 homolog, double strand break repair protein; RAD50 PEN; RAD50-2; RAD50-3
基因别名: hRad50; NBSLD; RAD50; RAD502
UniProt ID: (Human) Q92878
Entrez Gene ID: (Human) 10111
single-stranded DNA endodeoxyribonuclease activity
DNA binding
double-stranded telomeric DNA binding
ATP-dependent DNA helicase activity
adenylate kinase activity
protein binding
ATP binding
3'-5' exonuclease activity
protein binding, bridging
single-stranded telomeric DNA binding
metal ion binding
G-quadruplex DNA binding
regulation of mitotic recombination
telomere maintenance via recombination
telomere maintenance
double-strand break repair via homologous recombination
DNA double-strand break processing
DNA synthesis involved in DNA repair
strand displacement
DNA replication
DNA repair
double-strand break repair
double-strand break repair via nonhomologous end joining
DNA recombination
cellular response to DNA damage stimulus
telomere maintenance via telomerase
reciprocal meiotic recombination
viral process
telomeric 3' overhang formation
positive regulation of protein autophosphorylation
positive regulation of telomere maintenance
DNA duplex unwinding
positive regulation of kinase activity
nucleotide phosphorylation
chromosome organization involved in meiotic cell cycle
nucleic acid phosphodiester bond hydrolysis
regulation of signal transduction by p53 class mediator
negative regulation of telomere capping
