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Invitrogen
RADIL Polyclonal Antibody
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产品信息
PA5-62479
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: YGTHFIMSPP TKSKLKRQSQ LLSSMLSRTL SYKYRDLDST FSSLGASDDP AELSTQLSAP GVLKVFGDSV CTGTHYKSVL A
Highest antigen sequence identity to the following orthologs: Mouse - 93%, Rat - 95%.
靶标信息
Radil is a broadly expressed adapter protein that contains a RA-like domain, a PDZ domain and a DIL domain. Like RAPL and RIAM, Radil interacts preferentially with active GTP-bound Rap1, and overexpression of Radil enhances integrin-mediated adhesion. In addition, Radil knock down inhibits cell-substrate adhesion in HT1080, AD293, and NMuMG cells and results in migration defects in SW1353 and zebrafish neural crest cells. Radil regulates neutrophil adhesion by specifically enhancing beta2-integrin activation, as well as focal adhesion kinase (FAK) and paxillin phosphorylation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Rap GTPase interactor; Ras association and DIL domains; Ras-associating and dilute domain-containing protein
基因别名: KIAA1849; RADIL; RASIP2
UniProt ID: (Human) Q96JH8
Entrez Gene ID: (Human) 55698
