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Invitrogen
RAG1 Polyclonal Antibody
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产品信息
PA5-85711
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein encompassing a sequence within the C-terminus region of human RAG1. The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
0.85 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 20% glycerol
内含物
0.025% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Keep as concentrated solution.
Predicted reactivity: Mouse (96%), Rat (95%), Xenopus laevis (84%), Pig (90%), Rabbit (96%), Chicken (86%), Rhesus Monkey (98%).
Positive Control: Molt-4.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
The protein encoded by this gene is involved in activation of immunoglobulin V-D-J recombination. The encoded protein is involved in recognition of the DNA substrate, but stable binding and cleavage activity also requires RAG2. Defects in this gene can be the cause of several diseases.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: MGC43321; RAG-1; RAG-1 Antibody; recombination activating gene 1 Antibody; recombination activating protein 1; RING finger protein 74; RNF74 Antibody; V(D)J recombination-activating protein 1
基因别名: RAG-1; RAG1; RNF74
UniProt ID: (Human) P15918
Entrez Gene ID: (Human) 5896
DNA binding
endonuclease activity
ubiquitin-protein transferase activity
protein binding
zinc ion binding
ligase activity
histone binding
protein homodimerization activity
sequence-specific DNA binding
metal ion binding
ubiquitin protein ligase activity
DNA metabolism protein
endodeoxyribonuclease
nucleic acid metabolism protein
adaptive immune response
pre-B cell allelic exclusion
DNA recombination
immune response
histone monoubiquitination
B cell differentiation
T cell differentiation in thymus
V(D)J recombination
T cell homeostasis
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of T cell differentiation
thymus development
protein autoubiquitination
negative regulation of thymocyte apoptotic process
nucleic acid phosphodiester bond hydrolysis
