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Invitrogen
RALA Recombinant Rabbit Monoclonal Antibody (JE54-12)
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RALA Antibody (MA5-50740) in IHC (P)
Immunohistochemistry of RALA in paraffin-embedded human colon carcinoma tissue. The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 20 minutes. The tissues were blocked in 1% BSA for 20 minutes at room temperature, washed with ddH2O and PBS, and then probed with RALA recombinant monoclonal antibody (Product # MA5-50740) with a dilution of 1:200 for 1 hour at ... View More
产品信息
MA5-50740
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
JE54-12
抗原
Recombinant protein within Human RALA aa 107-206/206.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
TBS, pH 7.4, with 0.05% BSA, 40% glycerol
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive control: LOVO cell lysate, HCT116 cell lysate, HT-29 cell lysate, SW480 cell lysate, 293 cell lysate, human kidney tissue lysate, human colon tissue, human colon carcinoma tissue, human kidney tissue, HUVEC.
Predicted band size: 24 kDa
Subcellular Location: Cell membrane, Mitochondrion.
靶标信息
Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Plays a role in the early stages of cytokinesis and is required to tether the exocyst to the cytokinetic furrow. The RALA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling. Key regulator of LPAR1 signaling and competes with GRK2 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: MGC48949; Ras family small GTP binding protein RALA; ras related GTP binding protein A; RAS-like protein A; Ras-related protein Ral-A; v-ral simian leukemia viral oncogene homolog A (ras related)
基因别名: RAL; RALA
UniProt ID: (Human) P11233
Entrez Gene ID: (Human) 5898
