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Invitrogen
RAMP3 Polyclonal Antibody
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产品信息
PA5-117067
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-118 of human RAMP3 (NP_0058471)
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive Samples: MCF7, SW620, Mouse brain, Mouse skin, Mouse kidney, Mouse heart, Mouse eye, Rat brain, Rat lung
Immunogen sequence: METGALRRPQ LLPLLLLLCG GCPRAGGCNE TGMLERLPLC GKAFADMMGK VDVWKWCNLS EFIVYYESFT NCTEMEANVV GCYWPNPLAQ GFITGIHRQF FSNCTVDRVH LEDPPDEV
靶标信息
The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP3) protein, CRLR functions as an adrenomedullin receptor.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: calcitonin receptor-like receptor activity modifying protein 3; Calcitonin-receptor-like receptor activity-modifying protein 3; CRLR activity-modifying protein 3; receptor (calcitonin) activity modifying protein 3; receptor activity modifying protein 3; Receptor activity-modifying protein 3; receptor-activity-modifying protein 3
基因别名: AI850306; RAMP3
UniProt ID: (Human) O60896, (Mouse) Q9WUP1, (Rat) Q9JJ73
Entrez Gene ID: (Human) 10268, (Mouse) 56089, (Rat) 56820
positive regulation of receptor recycling
calcium ion transport
intracellular protein transport
regulation of G-protein coupled receptor protein signaling pathway
protein transport
receptor internalization
negative regulation of transcription, DNA-templated
cellular response to estradiol stimulus
protein localization to plasma membrane
G-protein coupled receptor signaling pathway involved in heart process
positive regulation of establishment of protein localization to plasma membrane
transport
signal transduction
G-protein coupled receptor signaling pathway
