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Invitrogen
RANGAP1 Monoclonal Antibody (K52049_6F3)
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RANGAP1 Antibody (MA5-55954) in IHC (P)
Immunohistochemistry analysis of RANGAP1 in paraffin-embedded kidney tissue. Sample was incubated with RANGAP1 monoclonal antibody (Product # MA5-55954) at a dilution of 1 µg/mL (RT, 1 hour). Antigen was retrieved through addition of boiling Tris/EDTA buffer pH 9 in a pressure cooker for 3 min. Endogenous peroxidase activity was quenched by incubating the sections with 3% H2O2 for 30 min at room temperature... View More
产品信息
MA5-55954
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
K52049_6F3
抗原
Recombinant human RANGAP1 (immunogen range is 251-370).
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID
产品详细信息
Sequence of this protein is as follows: KGAVAMAETL KTLRQVEVIN FGDCLVRSKG AVAIADAIRG GLPKLKELNL SFCEIKRDAA LAVAEAMADK AELEKLDLNG NTLGEEGCEQ LQEVLEGFNM AKVLASLSDD EDEEEEEEGE
靶标信息
Ran is a small signaling GTPase that is involved in nucleocytoplasmic transport. Two additional functions of animal Ran in the formation of spindle asters and the reassembly of the nuclear envelope in mitotic cells have been recently reported. In contrast to Ras or Rho, Ran is not associated with membranes. Instead, the spatial sequestering of its accessory proteins, the Ran GTPase-activating protein RanGAP and the nucleotide exchange factor RCC1, appears to define the local concentration of RanGTP vs. RanGDP involved in signaling. Mammalian RanGAP is bound to the nuclear pore by a mechanism involving the attachment of small ubiquitin-related modifier protein (SUMO) to its C terminus and the subsequent binding of the SUMOylated domain to the nucleoporin Nup358.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: MGC20266; Ran GTPase-activating protein 1; RanGAP1; segregation distorter homolog; segregation distortion
基因别名: Fug1; KIAA1835; RANGAP; RANGAP1; SD
UniProt ID: (Human) P46060
Entrez Gene ID: (Human) 5905
