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Invitrogen
RAP1A Polyclonal Antibody
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产品信息
PA1-29451
产品规格
种属反应
Human,
Mouse,
Rabbit,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to a portion of human Rap1a. Peptide differs from Rap1b by two residues.
偶联物
形式
Liquid
浓度
0.95 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
It is expected to cross-react with zebrafish and C. elegans based on sequence homology of 100% and 94%, respectively.
PA1-29451 has been successfully used in Western blot applications where a band of 25 kDa is detected. Positive control: rat brain tissue extract.
靶标信息
The product of this gene belongs to the family of RAS-related proteins. These proteins share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between RAP proteins and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. The product of this gene counteracts the mitogenic function of RAS because it can interact with RAS GAPs and RAF in a competitive manner. Two transcript variants encoding the same protein have been identified for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: C21KG; G-22K; GTP-binding protein smg p21A; GTP-binding protein SMG-P21A; RAS-related protein 1a; Ras-related protein Krev-1; Ras-related protein Rap-1A
基因别名: AI848598; C21KG; G-22K; KREV-1; KREV1; rap 1A; RAP-1A; RAP1; RAP1A; SMGP21
UniProt ID: (Human) P62834, (Mouse) P62835, (Rat) P62836
Entrez Gene ID: (Rabbit) 100351588, (Human) 5906, (Mouse) 109905, (Rat) 295347
activation of MAPKK activity
signal transduction
positive regulation of neuron projection development
protein transport
microvillus assembly
Rap protein signal transduction
negative regulation of collagen biosynthetic process
cellular response to drug
nerve growth factor signaling pathway
positive regulation of GTPase activity
positive regulation of protein kinase activity
positive regulation of glucose import
positive regulation of phagocytosis
regulation of insulin secretion
establishment of endothelial barrier
positive regulation of ERK1 and ERK2 cascade
cellular response to cAMP
cellular response to glucose stimulus
response to antineoplastic agent
liver regeneration
regulation of cell junction assembly
cellular response to nerve growth factor stimulus
negative regulation of synaptic vesicle exocytosis
positive regulation of vasculogenesis
small GTPase mediated signal transduction
nervous system development
metabolic process
