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Abnova
RARRES2 Monoclonal Antibody (3E3)
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产品信息
H00005919-M15
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
3E3
抗原
RARRES2 (NP_002880.1, 17 a.a. approximately 163 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
See Label
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Sequence of this protein is as follows: VGVAELTEAQ RRGLQVALEE FHKHPPVQWA FQETSVESAV DTPFPAGIFV RLEFKLQQTS CRKRDWKKPE CKVRPNGRKR KCLACIKLGS EDKVLGRLVH CPIETQVLRE AEEHQETQCL RVQRAGEDPH SFYFPGQFAF SKALPRS
靶标信息
Retinoids act through ligand-dependent transcription factors, retinoid X receptor (RXRs) and retinoic acid receptors (RARs). Tazarotene-induced gene (TIG) proteins, also designated retinoic acid receptor responder proteins or RAR-responsive proteins, can be membrane bound or secreted. TIGs act as tumor suppressor genes in human cancers and are highly expressed in skin, hair follicles and endothelial cells as well as in pancreas, spleen and intestine. TIGs are activated by tazarotene and have been implicated as growth regulators that mediate the growth suppressive effects of retinoids. TIG2 is a secreted protein that is mainly expressed in epidermis, hair follicles and endothelial cells. TIG2 is inhibited in psoriatic lesions and is activated by tazarotene in skin rafts and in epidermis of psoriatic lesions.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Chemerin; RAR-responsive protein TIG2; retinoic acid receptor responder (tazarotene induced) 2; Retinoic acid receptor responder protein 2; Tazarotene-induced gene 2 protein; TIG-2; TIG2HP10433
基因别名: HP10433; RARRES2; TIG2
UniProt ID: (Human) Q99969
Entrez Gene ID: (Human) 5919
retinoid metabolic process
in utero embryonic development
positive regulation of protein phosphorylation
platelet degranulation
chemotaxis
inflammatory response
positive regulation of macrophage chemotaxis
positive regulation of fat cell differentiation
embryonic digestive tract development
brown fat cell differentiation
positive regulation of chemotaxis
regulation of lipid catabolic process
positive regulation of glucose import in response to insulin stimulus
