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Invitrogen
RASA3 Polyclonal Antibody
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产品信息
PA5-75516
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to amino acids 290-335 of Human RASA3.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
靶标信息
Human GAP1-InsP4 BP, also designated Ras p21 protein activator (GTPase-activating protein) 3 [Ins(1,3,4,5)P4-binding protein], is an 829-amino acid protein that binds phospholipids in both a calcium-dependent and -independent manner. GAP1, one of the Ras GTPase-activating protein families, comprises four distinct genes, including GAP1(m), GAP1-InsP4 BP, MRASAL (murine Ras GTPase-activating-like) and KIAA0538. This family contains an N-terminal tandem C2 domain, a GAP-related domain and a C-terminal pleckstrin homology (PH) domain. The PH domains of GAP1-InsP4 BP are essential for membrane targeting via binding of specific phospholipids. Following agonist-stimulated PtdIns(3,4,5)P(3) production, group I family PH domain containing proteins like GAP1-InsP4 BP specifically bind inositol phosphates, which are subsequently targeted to the plasma membrane.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: GAP1(IP4BP); GAP1-InsP4 BP; GapIII; GAPIII activator 3; GTPase activating protein III; GTPase-activating protein 1 family, inositol 1,3,4,5-tetrakisphosphate-binding protein; Ins P4-binding protein; Ins(1,3,4,5)P4-binding protein; R-Ras gap; R-Ras GTP activating protein; R-ras GTPase activating protein; R-ras RTPase activating protein-3; Ras GTPase-activating protein 3; Ras GTPase-activating protein III; RP11-245B11.3
基因别名: AI326412; C86362; E130011G04; GAP1IP4BP; GAPIII; R-ras gap; RASA3; scat
UniProt ID: (Human) Q14644, (Mouse) Q60790, (Rat) Q9QYJ2
Entrez Gene ID: (Human) 22821, (Mouse) 19414, (Rat) 29372
MAPK cascade
signal transduction
positive regulation of GTPase activity
negative regulation of Ras protein signal transduction
release of sequestered calcium ion into cytosol
cellular response to heat
intracellular signal transduction
regulation of GTPase activity
calcium ion transmembrane transport
