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Invitrogen
RASA4 Polyclonal Antibody
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RASA4 Antibody (PA5-115826) in IHC (P)
Immunohistochemistry analysis of RASA4 in human prostate cancer and para-carcinoma tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with RASA4 polyclonal antibody (Product # PA5-115826) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
产品信息
PA5-115826
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human RASA4(Accession O43374), corresponding to amino acid residues V671-L721.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total RASA4.
靶标信息
This gene encodes a member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogen-activated protein kinase pathway in response to Ca(2+). Stimuli that increase intracellular Ca(2+) levels result in the translocation of this protein to the plasma membrane, where it activates Ras GTPase activity. Consequently, Ras is converted from the active GTP-bound state to the inactive GDP-bound state and no longer activates downstream pathways that regulate gene expression, cell growth, and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Ca2+-promoted Ras inactivator; Ca2+promoted Ras inactivator; Calcium-promoted Ras inactivator; Ras GTPase-activating protein 4; Ras p21 protein activator 4; RasGAP-activating-like protein 2
基因别名: AA793972; AW112107; BB079060; CAPRI; GAPL; KIAA0538; RASA4
UniProt ID: (Human) O43374, (Mouse) Q6PFQ7
Entrez Gene ID: (Human) 10156, (Mouse) 54153
