Invitrogen

RASGRP4 Polyclonal Antibody

Name: RASGRP4 Polyclonal Antibody
Brand: Invitrogen
SKU: PA5-21597

查看其他5个RASGRP4抗体

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

抗体检测数据 (3)

RASGRP4 Antibody in Immunocytochemistry (ICC/IF)

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RASGRP4 Antibody (PA5-21597) in ICC/IF

Immunofluorescence analysis of methanol-fixed HeLa, using RASGRP4 antibody (Product # PA5-21597) at 1:500 dilution.

RASGRP4 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Immunogen image

Immunogen Image RASGRP4 Polyclonal Antibody

产品信息

PA5-21597

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:3,000

免疫组化（石蜡） (IHC (P))

1:100-1:1,000

免疫细胞化学 (ICC/IF)

1:100-1:1,000

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human RASGRP4. The exact sequence is proprietary.

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7, with 40% glycerol

内含物

0.01% thimerosal

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

AB_11152222

产品详细信息

Recommended positive controls: Jurkat.

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

靶标信息

The RASGRP4 (RAS Guanyl Releasing Protein 4) gene encodes a guanine nucleotide exchange factor (GEF) that specifically activates RAS proteins by facilitating the exchange of GDP for GTP. Located on chromosome 19, RASGRP4 is expressed primarily in hematopoietic cells, including mast cells and certain myeloid cells. The protein contains a diacylglycerol (DAG)-binding C1 domain, a Ras exchange motif, and a CDC25 domain, which are essential for its activation and function. RASGRP4 plays a pivotal role in signal transduction pathways that regulate cell proliferation, differentiation, and survival. Dysregulation of RASGRP4 has been linked to various diseases, including inflammatory disorders and cancers, particularly those involving the hematopoietic system. Studies have shown that overexpression or mutations in RASGRP4 can lead to aberrant RAS signaling, contributing to oncogenesis and disease progression.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

仅用于科研。不用于诊断过程。未经明确授权不得转售。