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Sequence of this protein is as follows: MIQDKEVTLE YVSSLDFWYC KRCKANIGGH RSSCSFCKNP REVTEAKQEL ITYPQPQKTS IPAPLEKQPN QPLRPADKEP EPRKREEGQE SRLGHQKREA ERYLPPSRRE GPTFRRDRER ESWSGETRQD GESKTIMLKR IYRSTPPEVI VEVLEPYVRL TTANVRIIKN RTGPMGHTYG FIDLDSHAEA LRVVKILQNL DPPFSIDGKM VAVNLATGKR RNDSGDHSDH MHYYQGKKYF RDRRGGGRNS DWSSDTNRQG QQSSSDCYIY DSATGYYYDP LAGTYYDPNT QQEVYVPQDP GLPEEEEIKE KKPTSQGKSS SKKEMSKRDG KEKKDRGVTR FQENASEGKA PAEDVFKKPL PPTVKKEESP PPPKVVNPLI GLLGEYGGDS DYEEEEEEEQ TPPPQPRTAQ PQKREEQTKK ENEEDKLTDW NKLACLLCRR QFPNKEVLIK HQQLSDLHKQ NLEIHRKIKQ SEQELAYLER REREGKFKGR GNDRREKLQS FDSPERKRIK YSRETDSDRK LVDKEDIDTS SKGGCVQQAT GWRKGTGLGY GHPGLASSEE AEGRMRGPSV GASGRTSKRQ SNETYRDAVR RVMFARYKEL D
DEF-3 and LUCA15 belong to an evolutionarily conserved family of RNA binding proteins and share similar expression patterns. Both DEF-3 and LUCA15 are highly expressed in adult heart and thymus as well as fetal kidney. Conversely, fetal thymus and adult kidney express very little DEF-3 and LUCA15. In the haemopoietic system of mice, the expression of DEF-3 is downregulated upon differentiation of progenitor cells into granulocytes but persists during macrophage development. Both DEF-3 and LUCA15 contain two zinc finger motifs, a bipartite nuclear signal and two RNA binding motifs. DEF-3 and LUCA15 are capable of specifically binding poly(G) RNA.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: ETK2; HEK2; Lung cancer antigen NY-LU-12; lung cancer protooncogene 11; Protein G16; RNA-binding motif protein 6; RNA-binding protein 6; RNA-binding protein DEF-3; TYRO6
基因别名: 3G2; DEF-3; DEF3; g16; HLC-11; NY-LU-12; RBM6
UniProt ID: (Human) P78332
Entrez Gene ID: (Human) 10180