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Agrisera
RDR2/RNA-dependent RNA polymerase 2 Polyclonal Antibody
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RDR2/RNA-dependent RNA polymerase 2 Antibody (AS15-3097) in WB
50 µg of total protein from Arabidopsis thaliana: rdr 2-1 mutant, T-DNA insertion first exon (a), 30 µg protein from wild-type Col-0 (b), 50 µg protein from wild-type Col-0 (c), extracted with extraction buffer (50 m M Tris p H 7.5; 150 m M Na Cl; 1 m M EDTA; 10% v/v Glycerin; 1 m M DTT, 1 x Complete Protease Inhibitor Cocktail, Roche) and denatured with LaemmLi buffer at 95°C/5 min., were separated on 7.5%... View More
产品信息
AS15-3097
产品规格
种属反应
Plant
宿主/亚型
Rabbit
分类
Polyclonal
类型
Antibody
抗原
KLH-conjugated peptide derived from Arabidopsis thaliana RDR2 sequence, located towards C-terminal part of the protein.
偶联物
形式
Lyophilized
规格
200 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.
For reconstitution add 50 µL of sterile water.
Specific Species Reactivity: Arabidopsis thaliana
靶标信息
RDR2 encodes a nuclear RNA-dependent RNA polymerase that functions in the RNA-directed DNA methylation pathway by converting plant-specific RNA polymerase IV transcripts from repetitive, heterochromatic regions (including many transposable elements) into double-stranded RNA that is subsequently processed into predominantly 24-nt small interfering RNAs to guide transcriptional silencing and genome stability. The gene is protein-coding and produces an RDR2 protein that localizes to the nucleus and is also observed in nucleolar-associated siRNA processing centers together with other pathway components. Structurally, the locus comprises 4 exons and encodes a large, eukaryotic-type RNA-dependent RNA polymerase containing a conserved catalytic RdRP core domain; biochemical and structural work indicates RDR2 engages RNA templates (including RNA within RNA/DNA hybrids under defined end-structure constraints) and initiates complementary-strand synthesis near template 3' ends, consistent with tight functional coupling to polymerase IV transcription.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: AtRDR2; RNA-dependent RNA polymerase 2; SILENCING MOVEMENT DEFICIENT 1; SMD1; T22B4.110; T22B4_110
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