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Invitrogen
REPIN1 Recombinant Rabbit Monoclonal Antibody (2X2E9)
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REPIN1 Antibody (MA5-57992) in IHC (P)
Immunohistochemistry analysis of REPIN1 with paraffin-embedded Human colon carcinoma tissue. The tissue was incubated with REPIN1 Recombinant Monoclonal Antibody (Product # MA5-57992) using a 1:200 dilution (40x lens). High pressure antigen retrieval performed with 0.01M Citrate Buffer (pH 6.0) prior to staining.
产品信息
MA5-57992
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
2X2E9
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 376-567 of human REPIN1 (NP_037532.2).
偶联物
形式
Liquid
浓度
1.01 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Dry ice (international)
RRID
产品详细信息
Immunogen sequence: SCDDCGRSFR LERFLRAHQR QHTGERPFTC AECGKNFGKK THLVAHSRVH SGERPFACEE CGRRFSQGSH LAAHRRDHAP DRPFVCPDCG KAFRHKPYLA AHRRIHTGEK PYVCPDCGKA FSQKSNLVSH RRIHTGERPY ACPDCDRSFS QKSNLITHRK SHIRDGAFCC AICGQTFDDE ERLLAHQKKH DV
靶标信息
Replication initiator 1 (REPIN1) is a gene encoding a zinc-finger protein that plays a critical role in various metabolic processes. Located on chromosome 7 in humans, REPIN1 is prominently expressed in liver and adipose tissues. It is associated with the regulation of body weight and triglyceride levels, as evidenced by its locus within a quantitative trait locus (QTL) related to these metabolic traits. The REPIN1 protein is involved in enhancing DNA bending, which is crucial for replication initiation. Studies have shown that deleting REPIN1 in the liver can lead to improved insulin sensitivity and altered lipid metabolism, with secondary effects on adipose tissue. Additionally, REPIN1 is implicated in iron metabolism and apoptosis regulation, further underscoring its multifaceted role in cellular processes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 60 kDa origin-specific DNA-binding protein; 60 kDa replication initiation region protein; ATT-binding protein; DHFR oribeta-binding protein RIP60; DNA-binding protein REPIN1; H_DJ0584D14.12; replication initiation region protein (60kD); Zinc finger protein 464; zinc finger protein 464 (RIP60); zinc finger protein AP4
基因别名: AP4; REPIN1; RIP60; Zfp464; ZNF464
UniProt ID: (Human) Q9BWE0
Entrez Gene ID: (Human) 29803
