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Invitrogen
REST Recombinant Rabbit Monoclonal Antibody (8R8Z4)
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REST Antibody (MA5-35361) in WB
Western blot analysis of REST in extracts of various cell lines. Samples were incubated with REST Monoclonal antibody (Product # MA5-35361) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.
产品信息
MA5-35361
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
8R8Z4
抗原
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human REST/NRSF (Q13127)
偶联物
形式
Liquid
浓度
0.27 mg/mL
规格
27 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: KGEPHGLENM ELRSLELSVV EPQPVFEASG APDIYSSNKD LPPETPGAED KGKSSKTKPF RCKPCQYEAE SEEQFVHHIR VHSAKKFFVE ESAEKQAKAR E
靶标信息
Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Neural-restrictive silencer factor; neuron restrictive silencer factor; RE1-silencing transcription factor; repressor binding to the X2 box; transcription factor; X2 box repressor; zinc finger transcription factor REST protein
基因别名: 2610008J04Rik; AA407358; DFNA27; GINGF5; HGF5; NRSF; REST; REST4; WT6; XBR
UniProt ID: (Human) Q13127, (Mouse) Q8VIG1, (Rat) O54963
Entrez Gene ID: (Human) 5978, (Mouse) 19712, (Rat) 83618
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II core promoter sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
zinc ion binding
identical protein binding
sequence-specific DNA binding
metal ion binding
RNA polymerase II sequence-specific DNA binding transcription factor binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
core promoter sequence-specific DNA binding
core promoter binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
nucleic acid binding
transcription factor binding
outward rectifier potassium channel activity
protein complex binding
transcription regulatory region DNA binding
C2H2 zinc finger transcription factor
negative regulation of transcription from RNA polymerase II promoter
regulation of alternative mRNA splicing, via spliceosome
response to hypoxia
hematopoietic progenitor cell differentiation
response to ischemia
chromatin remodeling
regulation of transcription, DNA-templated
response to stress
regulation of gene expression
positive regulation of gene expression
negative regulation of gene expression
negative regulation of aldosterone biosynthetic process
cellular response to stress
somatic stem cell population maintenance
positive regulation of programmed cell death
negative regulation by host of viral transcription
negative regulation of neuron differentiation
positive regulation of neuron differentiation
regulation of osteoblast differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of calcium ion-dependent exocytosis
negative regulation of insulin secretion
negative regulation of neurogenesis
neurological system process
neuromuscular process controlling balance
detection of mechanical stimulus involved in sensory perception of sound
auditory receptor cell stereocilium organization
cardiac muscle cell myoblast differentiation
cellular response to electrical stimulus
cellular response to glucocorticoid stimulus
neuronal stem cell population maintenance
modification of synaptic structure
positive regulation of stem cell population maintenance
negative regulation of pri-miRNA transcription from RNA polymerase II promoter
negative regulation of cortisol biosynthetic process
negative regulation of dense core granule biogenesis
negative regulation of mesenchymal stem cell differentiation
negative regulation of amniotic stem cell differentiation
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
negative regulation of cell proliferation
regulation of ion transmembrane transport
cellular response to drug
positive regulation of apoptotic process
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
histone H4 deacetylation
potassium ion transmembrane transport
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