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Abnova
RGL1 Monoclonal Antibody (3E10)
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产品信息
H00023179-M02
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
3E10
抗原
RGL1 (NP_055964, 2 a.a. approximately 109 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
0.8 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Sandwich ELISA (Recombinant protein).
Immunogen sequence: EVKPVGEPTQ EVSKFKLSTK VESTGHWLVE DHVRIWEVLK TEESSIQDWG EEVEEGAVYH VTLKRVQIQQ AANKGARWLG VEGDQLPPGH TVSQYETCKI RTIKAGTL
靶标信息
Ral GDS (Ral guanine nucleotide dissociation stimulator) is a guanine nucleotide exchange factor (GEF) that activates Ral and is implicated in oncogenic Ras-induced cell transformation. RGL1 (ral guanine nucleotide dissociation stimulator-like 1), also known as RGL or RalGDS-like 1, is a 768 amino acid protein that is a putative GEF. Strongly expressed in brain, heart, spleen, kidney and testis, RGL1 is a downstream effector protein that is involved in Ras and Ral signaling pathways. RGL1 contains an N-terminal Ras-GEF domain and a C-terminal Ras-interacting domain that interacts with the GTP-bound form of Ras through its effector loop. Due to its similarity to Ral GDS, RGL1 may be implicated in carcinogenesis. Two isoforms exist due to alternative splicing events.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Ral guanine nucleotide dissociation stimulator-like 1; RalGDS-like 1
基因别名: KIAA0959; RGL; RGL1
UniProt ID: (Human) Q9NZL6
Entrez Gene ID: (Human) 23179
