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Invitrogen
RGL4 Polyclonal Antibody
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产品信息
PA5-57492
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: KLLTNLPAAA VLSAQVYSAV LRGLWEENVC GTPGRTRVCT ALLYGQVCPF QDSTDGLRTI TSILFNWPPE NTSVYYQPPQ RSSFRIKLAF RNLSWPGLGL EDHQEIVLGQ LVLPEPNEAK PDDPAPRPGQ HAL
Highest antigen sequence identity to the following orthologs: Mouse - 20%, Rat - 20%.
靶标信息
Ral Guanine Nucleotide Dissociation Stimulator-Like 4 (RGL4) is a gene that encodes a member of the RalGDS family, which is involved in the regulation of the Ras signaling pathway. This gene is located on chromosome 22 and is highly expressed in various tissues, including the brain and reproductive organs. RGL4 is known to interact with RalA and RalB, small GTPases that play crucial roles in cellular processes such as vesicular trafficking, cytoskeleton dynamics, and cell proliferation. Studies have shown that the expression of RGL4 has significant implications in various cancers. For instance, low expression of RGL4 is associated with poor prognosis and increased immune infiltration in lung adenocarcinoma (LUAD). Conversely, overexpression of RGL4 has been correlated with resistance to Midostaurin in FLT3-ITD mutant acute myeloid leukemia (AML) samples. These findings highlight the gene's potential as a biomarker for prognosis and therapy response in certain cancers, making it a valuable target for further research and clinical applications.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: hRGR; Ral guanine nucleotide dissociation stimulator-like 4; Ral-GDS related protein Rgr; Ral-GDS-related protein; RalGDS related oncogene; RalGDS-like 4
基因别名: RGL4; RGR
UniProt ID: (Human) Q8IZJ4
Entrez Gene ID: (Human) 266747
