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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Immunogen sequence: LELDRLRLER MDRIEKERKH QKELELVEDV WRGEAQDLLS QIAQLQEENK QLMTNLSHKD VNFSEEEFQK HEGMSERERQ VMKKLKEV
Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 94%.
Plays a role in the regulation of cell shape and polarity. Plays a role in cellular protein transport, including protein transport away from primary cilia. Neuroprotective protein, which acts by sequestring GAPDH in the cytosol and prevent the apoptotic function of GAPDH in the nucleus. Competes with SIAH1 for binding GAPDH. Does not regulate lysosomal morphology and distribution (PubMed:14668488). Binds to RAB10 following LRRK2-mediated RAB10 phosphorylation which leads to inhibition of ciliogenesis (PubMed:30398148). [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Rab-interacting lysosomal-like protein 1; RILP-like protein 1
基因别名: RILPL1; RLP1
Entrez Gene ID: (Human) 353116