Invitrogen

RIP1 Monoclonal Antibody (CL11368)

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RIP1 Monoclonal Antibody (CL11368)

产品信息

MA5-44166

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1 µg/mL
-
产品规格

种属反应

Human

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

CL11368

抗原

Recombinant protein fragment of Human RIPK1 (Product #RP-91447).
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.95 mg/mL

纯化类型

Protein A

保存液

PBS, pH 7.2, with 40% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2926310

产品详细信息

The antibody solution should be gently mixed before use. Optimal concentrations and conditions for each application should be determined by the user.

Immunogen sequence: KEYSNENAVV KRMQSLQLDC VAVPSSRSNS ATEQPGSLHS SQGLGMGPVE ESWFAPSLEH PQEENEPSLQ SKLQDEANYH LYGSRMDRQT KQQPRQNVAY NREEERRRRV SHDPFAQQRP YENFQNTEGK GTAYSSAASH GNAV

Highest antigen sequence indentity to the following orthologs: Rat - 67%, Mouse - 63%.

靶标信息

Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necrosis-inducing complex.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: Cell death protein RIP; FLJ39204; OTTHUMP00000015955; receptor (TNFRSF)-interacting serine-threonine kinase 1; Receptor-interacting protein 1; receptor-interacting protein kinase 1; Receptor-interacting serine/threonine-protein kinase 1; RIP-1; RIP1 (CT); serine/threonine-protein kinase RIP

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基因别名: RIP; RIP-1; RIP1; RIPK1

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UniProt ID: (Human) Q13546

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Entrez Gene ID: (Human) 8737

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功能
protein kinase activity protein serine/threonine kinase activity death receptor binding protein binding ATP binding ubiquitin protein ligase binding protein complex binding identical protein binding death domain binding non-receptor serine/threonine protein kinase
参与通路
positive regulation of protein phosphorylation apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process I-kappaB kinase/NF-kappaB signaling activation of JUN kinase activity regulation of tumor necrosis factor-mediated signaling pathway regulation of necrotic cell death positive regulation of necrotic cell death positive regulation of interleukin-8 production positive regulation of tumor necrosis factor production tumor necrosis factor-mediated signaling pathway response to tumor necrosis factor TRIF-dependent toll-like receptor signaling pathway peptidyl-serine autophosphorylation positive regulation of apoptotic process positive regulation of programmed cell death positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of I-kappaB kinase/NF-kappaB signaling cellular protein catabolic process positive regulation of macrophage differentiation positive regulation of transcription from RNA polymerase II promoter positive regulation of JNK cascade protein autophosphorylation positive regulation of NF-kappaB transcription factor activity protein homooligomerization protein heterooligomerization positive regulation of necroptotic process T cell apoptotic process necroptotic process regulation of ATP:ADP antiporter activity cellular response to tumor necrosis factor cellular response to growth factor stimulus death-inducing signaling complex assembly apoptotic signaling pathway extrinsic apoptotic signaling pathway activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway ripoptosome assembly necroptotic signaling pathway ripoptosome assembly involved in necroptotic process regulation of extrinsic apoptotic signaling pathway via death domain receptors negative regulation of extrinsic apoptotic signaling pathway via death domain receptors positive regulation of hydrogen peroxide-induced cell death amyloid fibril formation positive regulation of reactive oxygen species metabolic process negative regulation of extrinsic apoptotic signaling pathway positive regulation of extrinsic apoptotic signaling pathway negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
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