Invitrogen

RIP2 Recombinant Rabbit Monoclonal Antibody (JE51-90)

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RIP2 Recombinant Rabbit Monoclonal Antibody (JE51-90)

产品信息

MA5-46619

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:1,000
-

免疫细胞化学 (ICC/IF)

1:100
-
产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

JE51-90

抗原

Synthetic peptide within human RIPK2 aa 500-540.
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

TBS, pH 7.4, with 0.05% BSA, 40% glycerol

内含物

0.05% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2937691

产品详细信息

Positive Control: PC-3M cell lysate, 22RV1 cell lysate, RWPE-1 cell lysate.

Subcellular Location: Cytoplasm.

Tissue Specificity: Detected in heart, brain, placenta, lung, peripheral blood leukocytes, spleen, kidney, testis, prostate, pancreas and lymph node.Low tissue specificity.

Sequence Similarities: 82% Mouse/Rat.

靶标信息

RIPK2 is a serine/threonine kinase that is involved in cell activation, proliferation, differentiation, and apoptosis. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. Contributes to the tyrosine phosphorylation of the guanine exchange factor ARHGEF2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Once recruited, RIPK2 autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases XIAP, BIRC2 and BIRC3. The polyubiquitinated protein mediates the recruitment of MAP3K7/TAK1 to IKBKG/NEMO and induces 'Lys-63'-linked polyubiquitination of IKBKG/NEMO and subsequent activation of IKBKB/IKKB. In turn, NF-kappa-B is released from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Plays also a role during engagement of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: CARD-carrying kinase; CARD-containing IL-1 beta ICE-kinase; CARD-containing interleukin-1 beta-converting enzyme (ICE)-associated kinase; CARD-containing interleukin-1 beta-converting enzyme-associated kinase; EC 2.7.11.1; growth-in; growth-inhibiting gene 30; kinase RIPK2; receptor-interacting protein (RIP)-like interacting caspase-like apoptosis regulatory protein (CLARP) kinase; Receptor-interacting protein 2; receptor-interacting serine-threonine kinase 2; Receptor-interacting serine/threonine-protein kinase 2; RIP 2; RIP-2; RIP-like; RIP-like-interacting CLARP kinase; Tyrosine-protein kinase RIPK2; WUGSC:H_RG437L15.1

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基因别名: CARD3; CARDIAK; CCK; GIG30; RICK; RIP2; RIPK2; UNQ277/PRO314/PRO34092

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UniProt ID: (Human) O43353

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Entrez Gene ID: (Human) 8767

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功能
protein serine/threonine kinase activity non-membrane spanning protein tyrosine kinase activity signal transducer activity receptor binding protein binding ATP binding LIM domain binding protein homodimerization activity CARD domain binding non-receptor serine/threonine protein kinase
参与通路
activation of MAPK activity positive regulation of cytokine-mediated signaling pathway adaptive immune response apoptotic process inflammatory response signal transduction I-kappaB kinase/NF-kappaB signaling JNK cascade positive regulation of peptidyl-threonine phosphorylation peptidyl-tyrosine phosphorylation positive regulation of protein ubiquitination lipopolysaccharide-mediated signaling pathway positive regulation of chemokine production positive regulation of interferon-alpha production positive regulation of interferon-beta production positive regulation of interferon-gamma production positive regulation of interleukin-12 production positive regulation of interleukin-2 production positive regulation of interleukin-6 production positive regulation of tumor necrosis factor production positive regulation of immature T cell proliferation positive regulation of peptidyl-serine phosphorylation toll-like receptor 2 signaling pathway toll-like receptor 4 signaling pathway T cell proliferation positive regulation of apoptotic process negative regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling response to exogenous dsRNA innate immune response positive regulation of T-helper 1 cell differentiation positive regulation of transcription from RNA polymerase II promoter positive regulation of JNK cascade positive regulation of alpha-beta T cell proliferation positive regulation of peptidyl-tyrosine phosphorylation defense response to Gram-positive bacterium T cell receptor signaling pathway positive regulation of NF-kappaB transcription factor activity positive regulation of ERK1 and ERK2 cascade nucleotide-binding oligomerization domain containing signaling pathway nucleotide-binding oligomerization domain containing 1 signaling pathway nucleotide-binding oligomerization domain containing 2 signaling pathway response to interleukin-1 response to interleukin-12 response to interleukin-18 cellular response to lipoteichoic acid cellular response to peptidoglycan cellular response to muramyl dipeptide positive regulation of xenophagy
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