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Rockland
RKHD2 Polyclonal Antibody
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FIGURE: 1 / 1
RKHD2 Antibody (600-401-EA5) in WB
Western Blot of Rkhd2 antibody. Lane A: Rat heart tissue lysate at 0.5 µg/mL. Lane B: Rat heart tissue lysate at 1 µg/mL. Load: 35 µg per lane. Secondary antibody: Peroxidase rabbit secondary antibody at 1:10,000 for 45 min at RT. Block: 5% BLOTTO overnight at 4°C. Predicted/Observed size: 69.3 kDa, ~70 kDa for Rkhd2.
Product Details
600-401-EA5
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Anti-Rkhd2 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 15 amino acid synthetic peptide from near the C-terminus of human RKHD2.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Rkhd2, also known as MEX3C is a member of a novel family of four homologous human MEX3 proteins each containing two heterogeneous nuclear ribonucleoprotein K homology (KH) domains and one carboxy-terminal RING finger module. MEX3 proteins, including Rkhd2, are phosphoproteins that bind RNA through their KH domains and shuttle between the nucleus and the cytoplasm via the CRM1 export pathway. These proteins are a novel family of evolutionarily conserved RNA-binding proteins, differentially recruited to P bodies and potentially involved in post-transcriptional regulatory mechanisms. It has been suggested that genetic variations in Rkhd2 may be associated with susceptibility to essential hypertension type 8. Rkhd3 and Rkhd4, but not Rkhd2, co-localize with both the hDcp1a decapping factor and Argonaute (Ago) proteins in processing bodies (P bodies), recently characterized as centers of mRNA turnover.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: mex-3 homolog C; MEX3C variant 1; MEX3C variant 10; MEX3C variant 11; MEX3C variant 2; MEX3C variant 3; MEX3C variant 4; MEX3C variant 5; MEX3C variant 6; MEX3C variant 9; ring finger and KH domain containing 2; RING finger and KH domain-containing protein 2; RING finger protein 194; RING-type E3 ubiquitin transferase MEX3C; RNA-binding E3 ubiquitin-protein ligase MEX3C; RNA-binding protein MEX3C
Gene Aliases: A130001D14Rik; BC035207; BM-013; MEX-3C; MEX3C; RKHD2; RNF194
UniProt ID: (Human) Q5U5Q3, (Mouse) Q05A36
Entrez Gene ID: (Human) 51320, (Mouse) 240396, (Rat) 307271
protein binding
zinc ion binding
ligase activity
poly(A) RNA binding
nucleic acid binding
RNA binding
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
ribosomal S6-glutamic acid ligase activity
coenzyme F420-0 gamma-glutamyl ligase activity
coenzyme F420-2 alpha-glutamyl ligase activity
metal ion binding
protein-glycine ligase activity
protein-glycine ligase activity, initiating
protein-glycine ligase activity, elongating
tubulin-glycine ligase activity
protein-glutamic acid ligase activity
tubulin-glutamic acid ligase activity
RNA metabolism protein
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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