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Bethyl Laboratories
RLIP76 Polyclonal Antibody
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FIGURE: 1 / 2
RLIP76 Antibody (A304-498A) in WB
Detection of human RLIP76 by western blot. Samples: Whole cell lysate (50 µg) from HeLa, HEK293T, and Jurkat cells prepared using NETN lysis buffer. Antibodies: Affinity purified rabbit anti-RLIP76 antibody (Product # A304-498A) (lot A304-498A-1) used for WB at 0.1 µg/mL. Detection: Chemiluminescence with an exposure time of 30 seconds.
Product Details
A304-498A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 605 to 655 of Human 76 kDa Ral-Interacting Protein.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
phosphate/tris citrate, pH 7-8
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
Can specifically activate hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates ATP-dependent transport of S-(2,4-dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX) and is the major ATP-dependent transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes. Can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon. Serves as a scaffold protein that brings together proteins forming an endocytotic complex during interphase and also with CDC2 to switch off endocytosis, One of its substrates would be EPN1/Epsin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 76 kDa Ral-interacting protein; Dinitrophenyl S-glutathione ATPase; DNP-SG ATPase; Ral-interacting protein 1; RalA-binding protein 1; RalBP1; RIP; unnamed protein product
Gene Aliases: RALBP1; RIP1; RLIP; RLIP1; RLIP76
UniProt ID: (Human) Q15311
Entrez Gene ID: (Human) 10928
nucleotide binding
GTPase activator activity
protein binding
ATP binding
xenobiotic-transporting ATPase activity
glutathione S-conjugate-exporting ATPase activity
transmembrane transporter activity
small GTPase binding
ATPase activity, coupled to transmembrane movement of substances
xenobiotic transporter activity
positive regulation of protein phosphorylation
receptor-mediated endocytosis
chemotaxis
signal transduction
small GTPase mediated signal transduction
regulation of Cdc42 protein signal transduction
regulation of GTPase activity
positive regulation of GTPase activity
regulation of small GTPase mediated signal transduction
transmembrane transport
positive regulation of mitochondrial fission
doxorubicin transport
drug transmembrane export
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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