Search
Abnova
RNF139 Monoclonal Antibody (2D5)
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
H00011236-M02
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
2D5
抗原
RNF139 (NP_009149, 565 a.a. approximately 664 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Sandwich ELISA (Recombinant protein).
Immunogen sequence: HYFHALCLRK WLYIQDTCPM CHQKVYIEDD IKDNSNVSNN NGFIPPNETP EEAVREAAAE SDRELNEDDS TDCDDDVQRE RNGVIQHTGA AAEEFNDDTD
靶标信息
The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a ttranslocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: MGC31961; multiple membrane spanning receptor TRC8; patched related protein translocated in renal cancer; RING-type E3 ubiquitin transferase RNF139; translocation in renal carcinoma on chromosome 8 protein; translocation in renal carcinoma, chromosome 8; unnamed protein product
基因别名: HRCA1; RCA1; TRC8
UniProt ID: (Human) Q8WU17
Entrez Gene ID: (Human) 11236
negative regulation of cell proliferation
protein ubiquitination
negative regulation of translation
protein destabilization
ERAD pathway
proteasome-mediated ubiquitin-dependent protein catabolic process
regulation of ER to Golgi vesicle-mediated transport
regulation of protein processing
endoplasmic reticulum mannose trimming
positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
