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Abnova
RNF14 Polyclonal Antibody, MaxPab™
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产品信息
H00009604-D01P
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
RNF14 (NP_899645.1, 1 a.a. approximately 348 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
See Label
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Sequence of this protein is as follows: MQFLKEETLA YLNIVSPFEL KIGSQKKVQR RTAQASPNTE LDFGGAAGSD VDQEEIVDER AVQDVESLSN LIQEILDFDQ AQQIKCFNSK LFLCSICFCE KLGSECMYFL ECRHVYCKAC LKDYFEIQIR DGQVQCLNCP EPKCPSVATP GQVKELVEAE LFARYDRLLL QSSLDLMADV VYCPRPCCQL PVMQEPGCTM GICSSCNFAF CTLCRLTYHG VSPCKVTAEK LMDLRNEYLQ ADEANKRLLD QRYGKRVIQK ALEEMESKEW LEKNSKSCPC CGTPIEKLDG CNKMTCTGCM QYFCWICMGS LSRANPYKHF NDPGSPCFNR LFYAVDVDDD IWEDEVED
靶标信息
The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein interacts with androgen receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate. A dominant negative mutant of this gene has been demonstrated to inhibit the AR-mediated growth of prostate cancer. This protein also interacts with class III ubiquitin-conjugating enzymes (E2s) and may act as a ubiquitin-ligase (E3) in the ubiquitination of certain nuclear proteins. Five alternatively spliced transcript variants encoding two distinct isoforms have been reported.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: androgen receptor associated protein 54; Androgen receptor-associated protein 54; E3 ubiquitin-protein ligase RNF14; HFB30; RING finger protein 14
基因别名: ARA54; HFB30; HRIHFB2038; RNF14; TRIAD2
UniProt ID: (Human) Q9UBS8
Entrez Gene ID: (Human) 9604
protein polyubiquitination
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
signal transduction
protein ubiquitination
androgen receptor signaling pathway
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
positive regulation of transcription, DNA-templated
regulation of androgen receptor signaling pathway
