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Abnova
RNF144B Polyclonal Antibody, MaxPab™
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RNF144B Antibody (H00255488-D01P) in WB
Western Blot analysis of RNF144B expression in transfected 293T cell line (H00255488-T02) by RNF144B MaxPab polyclonal antibody.
Lane 1: RNF144B transfected lysate(33.60 KDa).
Lane 2: Non-transfected lysate.
Lane 1: RNF144B transfected lysate(33.60 KDa).
Lane 2: Non-transfected lysate.
产品信息
H00255488-D01P
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
RNF144B (AAH63311.1, 1 a.a. approximately 302 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
See Label
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Sequence of this protein is as follows: MGSAGRLHYL AMTAENPTPG DLAPAPLITC KLCLCEQSLD KMTTLQECQC IFCTACLKQY MQLAIREGCG SPITCPDMVC LNHGTLQEAE IACLVPVDQF QLYQRLKFER EVHLDPYRTW CPVADCQTVC PVASSDPGQP VLVECPSCHL KFCSCCKDAW HAEVSCRDSQ PIVLPTEHRA LFGTDAEAPI KQCPVCRVYI ERNEGCAQMM CKNCKHTFCW YCLQNLDNDI FLRHYDKGPC RNKLGHSRAS VMWNRTQVVG ILVGLGIIAL VTSPLLLASP CIICCVCKSC RGKKKKHDPS TT
靶标信息
E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: E3 ubiquitin-protein ligase RNF144B; IBR domain containing 2; IBR domain-containing protein 2; p53-inducible RING finger protein; RING finger protein 144B
基因别名: bA528A10.3; IBRDC2; P53RFP; PIR2; RNF144B
UniProt ID: (Human) Q7Z419
Entrez Gene ID: (Human) 255488
