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Abnova
RNF157 Monoclonal Antibody (6B3)
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产品信息
H00114804-M01
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
6B3
抗原
RNF157 (NP_443148, 556 a.a. approximately 655 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
0.33 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Sandwich ELISA (Recombinant protein).
Immunogen sequence: PASRAPSEEG EGLPAESPDS NFAGLPAGEQ DAEGNDVIEE EDGSPTQEGQ RTCAFLGMEC DNNNDFDIAS VKALDNKLCS EVCLPGAWQA DDNAVSRNAQ
靶标信息
E3 ubiquitin ligase that ubiquitinates APBB1 for its degradation by the proteasome and thus prevents apoptosis and promotes survival of neurons (PubMed:25342469). Has a dual role in neurons as it is also required for dendrite growth and maintenance for which its ligase activity is not critical (PubMed:25342469). May act as a scaffold molecule to regulate this process (PubMed:25342469). Acts as a downstream effector of the interconnected PI3K and MAPK signaling pathways and thus participates in the regulation of the cell cycle (PubMed:28655764). [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: E3 ubiquitin ligase RNF157; RING finger protein 157; RING-type E3 ubiquitin transferase RNF157
基因别名: KIAA1917; RNF157
UniProt ID: (Human) Q96PX1
Entrez Gene ID: (Human) 114804
