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Invitrogen
RNF8 Recombinant Rabbit Monoclonal Antibody (8M7D8)
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RNF8 Antibody (MA5-51454) in IHC (P)
Immunohistochemistry analysis of RNF8 in paraffin-embedded human testis. Samples were incubated with RNF8 Recombinant monoclonal antibody (Product # MA5-51454) using a dilution of 1:300 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-51454
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
8M7D8
抗原
Recombinant protein (or fragment)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.215 mg/mL
规格
21.5 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: MGEPGFFVTG DRAGGRSWCL RRVGMSAGWL LLEDGCEVTV GRGFGVTYQL VSKICPLMIS RNHCVLKQNP EGQWTIMDNK SLNGVWLNRA RLEPLRVYSI HQGDYIQLGV PLENKENAEY EYEVTEEDWE TIYPCLSPKN DQMIEKNKEL RTKRKFSLDE LAGPGAEGPS NLKSKINKVS CESGQPVKSQ GKGEVASTPS DNLDPKLTAL EPSKTTGAPI YPGFPKVTEV HHEQKASNSS ASQRSLQMFK VTMSRILRLK
靶标信息
The protein encoded by this gene contains a RING finger motif and a FHA domain. This protein has been shown to interact with several class II ubiquitin-conjugating enzymes (E2), including UBE2E1/UBCH6, UBE2E2, and UBE2E3, and may act as an ubiquitin ligase (E3) in the ubiquitination of certain nuclear proteins. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ActA binding protein 2; actA-interacting protein 37; C3HC4-type zinc finger protein; FLJ12013; OTTHUMP00000039684; ring finger protein (C3HC4 type) 8; ring finger protein 8, E3 ubiquitin protein ligase; RING-type E3 ubiquitin transferase RNF8; Rnf8; UBC13/UEV-interacting ring finger protein; unnamed protein product; UURF1
基因别名: 3830404E21Rik; AIP37; hRNF8; laXp180
UniProt ID: (Human) O76064, (Mouse) Q8VC56, (Rat) Q4KLN8
Entrez Gene ID: (Human) 9025, (Mouse) 58230, (Rat) 361815
double-strand break repair
double-strand break repair via nonhomologous end joining
chromatin organization
ubiquitin-dependent protein catabolic process
cellular response to DNA damage stimulus
response to ionizing radiation
protein ubiquitination
negative regulation of transcription elongation from RNA polymerase II promoter
sperm chromatin condensation
regulation of gene expression, epigenetic
signal transduction in response to DNA damage
isotype switching
positive regulation of DNA repair
protein autoubiquitination
protein K63-linked ubiquitination
protein K48-linked ubiquitination
protein K6-linked ubiquitination
DNA repair-dependent chromatin remodeling
positive regulation of double-strand break repair via homologous recombination
protein localization to site of double-strand break
biological_process
interstrand cross-link repair
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